Nasal Oxytocin for Social Deficits in Childhood Autism: A Randomized Controlled Trial
Nasal Oxytocin for Social Deficits in Childhood Autism: A Randomized Controlled Trial
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DOI：
10.1007/s10803-013-1899-3
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发表时间：
2014-03-01
影响因子：
3.9
通讯作者：
Brennan, John
中科院分区：
文献类型：
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作者：
Dadds, Mark R.;MacDonald, Elayne;Brennan, John
在过去的二十年里，研究催产素作为一种增强人类社会行为的方法的研究激增。初步证据表明催产素可能有潜力作为自闭症的干预措施。我们使用双盲随机对照试验评估了为期5天的“居住”干预。对38名患有自闭症谱系障碍的男性青年（7-16岁）给予24或12国际单位（取决于体重）鼻内安慰剂或催产素，每天一次，连续四天。催产素或安慰剂是在亲子互动训练课程期间施用的。父母和孩子的行为进行了评估，使用父母的报告，临床医生的评级，和独立的观察，在多个时间点，以衡量副作用;社会交往技能;重复行为;情绪识别和诊断状态。与安慰剂相比，鼻内催产素并没有显著改善患有自闭症谱系障碍的男性青年的情感识别、社交技能或一般行为调整。结果表明，鼻催产素对患有自闭症谱系障碍的年轻人的益处可能比以前的研究所建议的更为有限，并建议谨慎推荐它作为广泛有效的干预措施。
The last two decades have witnessed a surge in research investigating the application of oxytocin as a method of enhancing social behaviour in humans. Preliminary evidence suggests oxytocin may have potential as an intervention for autism. We evaluated a 5-day 'live-in' intervention using a double-blind randomized control trial. 38 male youths (7-16 years old) with autism spectrum disorders were administered 24 or 12 international units (depending on weight) intranasal placebo or oxytocin once daily over four consecutive days. The oxytocin or placebo was administered during parent-child interaction training sessions. Parent and child behaviours were assessed using parent reports, clinician ratings, and independent observations, at multiple time points to measure side-effects; social interaction skills; repetitive behaviours; emotion recognition and diagnostic status. Compared to placebo, intranasal oxytocin did not significantly improve emotion recognition, social interaction skills, or general behavioral adjustment in male youths with autism spectrum disorders. The results show that the benefits of nasal oxytocin for young individuals with autism spectrum disorders may be more circumscribed than suggested by previous studies, and suggest caution in recommending it as an intervention that is broadly effective.