Combined chemoradiotherapy regimens of paclitaxel and carboplatin for locally advanced non-small-cell lung cancer: A randomized phase II locally advanced multi-modality protocol
Combined chemoradiotherapy regimens of paclitaxel and carboplatin for locally advanced non-small-cell lung cancer: A randomized phase II locally advanced multi-modality protocol
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DOI：
10.1200/jco.2005.55.405
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发表时间：
2005-09-01
影响因子：
45.3
通讯作者：
Curran, WJ
中科院分区：
文献类型：
--
作者：
Belani, CP;Choy, H;Curran, WJ
目的：本研究为II期非比较性随机试验，旨在确定紫杉醇/卡铂联合标准每日胸部放疗（TRT）治疗局部晚期未切除的III期非小细胞肺癌（NSCLC）患者的最佳序贯和联合方案。患者和方法未切除的IIIA和IIIB期NSCLC患者，Karnofsky体能状态>= 70%，体重减轻，
Purpose This phase II noncomparative randomized trial was conducted to determine the optimal sequencing and integration of paclitaxel/carboplatin with standard daily thoracic radiation therapy (TRT), in patients with locally advanced unresected stage III non-small-cell lung cancer (NSCLC). Survival data were compared with historical standard sequential chemoradiotherapy data from the Radiation Therapy Oncology Group.Patients and Methods Patients with unresected stages IIIA and IIIB NSCLC, with Karnofsky performance status >= 70% and weight loss