Secondary membranous glomerulonephritis associated with recipient residual lymphoma cells after allogeneic bone marrow transplantation
Secondary membranous glomerulonephritis associated with recipient residual lymphoma cells after allogeneic bone marrow transplantation
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异基因骨髓移植后受者残留淋巴瘤细胞相关的继发性膜性肾炎
DOI：
10.1007/s10157-008-0120-z
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发表时间：
2009
影响因子：
2.3
通讯作者：
K. Yamagata
中科院分区：
文献类型：
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作者：
K. Sakai;J. Usui;H. Kai;M. Hagiwara;Naoki Morito;Chie Saito;K. Yoh;Syuichi Tsuruoka;K. Hirayama;K. Aita;Michio Nagata;K. Yamagata
一位29岁男性恶性淋巴瘤患者，在接受异基因骨髓移植后发生膜性肾病。骨髓移植后未发现明显的移植物抗宿主病（GVHD），免疫抑制剂的剂量在此期间未减少。在MN发病时，少数淋巴瘤细胞仍残留在骨髓中;患者在淋巴瘤细胞消失后达到MN的完全缓解。在这种情况下，它表明，免疫复合物，包括淋巴瘤细胞表达的抗原可能会诱导MN。因此，这是一个有意义的情况下，可能会揭示一个替代机制的MN的发病有关的骨髓移植。
A 29-year-old man with malignant lymphoma developed membranous nephropathy (MN) after allogeneic bone-marrow transplantation (BMT). There had been no obvious findings of graft versus host diseases (GVHD) after BMT, and the dosage of immunosuppressant drugs had not been reduced during this period. At the onset of MN, a few lymphoma cells still remained in the bone marrow; the patient achieved complete remission of MN after the disappearance of the lymphoma cells. In this case it is suggested that immune complexes including antigens expressed by lymphoma cells might induce MN. Therefore, this is a significant case that may reveal an alternative mechanism of the onset of MN related to BMT.
小山，A.，稻毛，H.，小林，M.，中村，H.，成田，M.，东条，S.：“抗原化学阳离子化对血清疾病活动模型中免疫复合物肾小球定位的影响
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