Early evolution of eukaryotic DNA-dependent RNA polymerases
Early evolution of eukaryotic DNA-dependent RNA polymerases
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DOI：
10.1016/j.tig.2008.02.002
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发表时间：
2008-05-01
影响因子：
11.4
通讯作者：
Thuriaux, Pierre
中科院分区：
文献类型：
--
作者：
Kwapisz, Marta;Beckouet, Frederic;Thuriaux, Pierre
真核生物依赖DNA的RNA聚合酶(POL I-III)共有一个由12个亚基组成的保守核心，与古生物RNA聚合酶密切相关。Rpb8是在Pol I、II和III中发现的一个亚基，被认为仅限于真核生物。我们在这里证明了Rpb8与一种名为G的古生菌蛋白非常相似，G蛋白只在文氏菌中发现，它确定了古生菌和真核RNA聚合酶的核心结构之间最后缺失的一环。
Eukaryotic DNA-dependent RNA polymerases (Pol I-III) share a conserved core of 12 subunits, which is closely related to archaeal RNA polymerases. Rpb8, a subunit found in Pol I, II and III, was thought to be restricted to eukaryotes. We show here that Rpb8 closely resembles an archaeal protein called G, found only in Crenarchaea, which identifies a last missing link between the core structure of archaeal and eukaryotic RNA polymerases.