Aqueous Phase Synthesis of Highly Luminescent, Nitrogen-Doped Carbon Dots and Their Application as Bioimaging Agents
Aqueous Phase Synthesis of Highly Luminescent, Nitrogen-Doped Carbon Dots and Their Application as Bioimaging Agents
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DOI：
10.1021/la5031813
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发表时间：
2014-12-02
期刊：
影响因子：
3.9
通讯作者：
Zhou, H. Susan
中科院分区：
文献类型：
--
作者：
Wang, Li;Yin, Yuan;Zhou, H. Susan
碳点具有荧光特性、良好的生物相容性和低毒性，是一种很有前途的多功能治疗系统支架材料。在本工作中，我们以叶酸为前驱体，通过水相法制备了氮掺杂碳点。碳点具有尺寸约为9 nm的均匀分散、明亮的光致发光、高达23%的光致发光量子产率和低毒等特点，使其成为生物医学应用的良好成像探针。
Carbon dots are promising scaffolds for multifunctional therapeutic systems because of their fluorescence property, good biocompatibility, and low toxicity. In this work, we prepared nitrogen-doped carbon dots through an aqueous phase strategy using folic acid as precursor. The carbon dots possess many attractive features including uniform dispersion with size about 9 nm, bright photoluminescence, high photoluminescence quantum yield of 23%, and low toxicity, making them excellent imaging probes for biomedical applications.