Heterogeneity of tumor-induced gene expression changes in the human metabolic network.
Heterogeneity of tumor-induced gene expression changes in the human metabolic network.
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DOI：
10.1038/nbt.2530
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发表时间：
2013-06
影响因子：
46.9
通讯作者：
中科院分区：
文献类型：
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细胞代谢的重编程是肿瘤转化的一个新兴标志。然而，目前尚不清楚肿瘤中的代谢基因表达与正常组织中的代谢基因表达有何不同，也不清楚不同的肿瘤类型是否表现出相似的代谢变化。在这里，我们比较了22种不同类型的人类肿瘤中代谢基因的表达模式。总体而言，肿瘤中的代谢基因表达程序与相应的正常组织相似。虽然一些代谢途径的表达变化（如核苷酸生物合成和糖酵解的上调）在肿瘤中经常观察到，但其他途径的表达变化（如氧化磷酸化和三羧酸（TCA）循环）是非常不均匀的。我们的分析还表明，肿瘤中主要代谢过程的表达变化可以用几个主要成分来解释。在个体生化反应水平上，数百种代谢同工酶表现出显著的肿瘤特异性表达变化。这些同工酶是抗癌治疗的潜在靶点。
Reprogramming of cellular metabolism is an emerging hallmark of neoplastic transformation. However, it is not known how metabolic gene expression in tumors differs from that in normal tissues, or whether different tumor types exhibit similar metabolic changes. Here we compare expression patterns of metabolic genes across 22 diverse types of human tumors. Overall, the metabolic gene expression program in tumors is similar to that in the corresponding normal tissues. Although expression changes of some metabolic pathways (e.g., up-regulation of nucleotide biosynthesis and glycolysis) are frequently observed across tumors, expression changes of other pathways (e.g., oxidative phosphorylation and the tricarboxylic acid (TCA) cycle) are very heterogeneous. Our analysis also suggests that the expression changes of major metabolic processes across tumors can be rationalized in terms of several principal components. On the level of individual biochemical reactions, many hundreds of metabolic isoenzymes show significant and tumor-specific expression changes. These isoenzymes are potential targets for anticancer therapy.
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影响因子：
30.8
作者：
通讯作者：
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
5.5
作者：
Glazko G;Mushegian A
通讯作者：
Mushegian A
丙酮酸激酶M2激活剂促进四聚体形成并抑制肿瘤发生。
影响因子：
14.8
作者：
Anastasiou, Dimitrios;Yu, Yimin;Israelsen, William J.;Jiang, Jian-Kang;Boxer, Matthew B.;Hong, Bum Soo;Tempel, Wolfram;Dimov, Svetoslav;Shen, Min;Jha, Abhishek;Yang, Hua;Mattaini, Katherine R.;Metallo, Christian M.;Fiske, Brian P.;Courtney, Kevin D.;Malstrom, Scott;Khan, Tahsin M.;Kung, Charles;Skoumbourdis, Amanda P.;Veith, Henrike;Southall, Noel;Walsh, Martin J.;Brimacombe, Kyle R.;Leister, William;Lunt, Sophia Y.;Johnson, Zachary R.;Yen, Katharine E.;Kunii, Kaiko;Davidson, Shawn M.;Christofk, Heather R.;Austin, Christopher P.;Inglese, James;Harris, Marian H.;Asara, John M.;Stephanopoulos, Gregory;Salituro, Francesco G.;Jin, Shengfang;Dang, Lenny;Auld, Douglas S.;Park, Hee-Won;Cantley, Lewis C.;Thomas, Craig J.;Heiden, Matthew G. Vander
通讯作者：
Heiden, Matthew G. Vander
影响因子：
14.9
作者：
Barrett T;Troup DB;Wilhite SE;Ledoux P;Evangelista C;Kim IF;Tomashevsky M;Marshall KA;Phillippy KH;Sherman PM;Muertter RN;Holko M;Ayanbule O;Yefanov A;Soboleva A
通讯作者：
Soboleva A