Replication and assembly of VSV nucleocapsids: protein association with RNPs and the effects of cycloheximide on replication.
Replication and assembly of VSV nucleocapsids: protein association with RNPs and the effects of cycloheximide on replication.
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DOI：
10.1016/0042-6822(80)90161-0
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发表时间：
1980-08
期刊：
影响因子：
3.7
通讯作者：
Cynthia Rubio;C. Kolakofsky;V. M. Hill;Donald F. Summers
中科院分区：
文献类型：
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作者：
Cynthia Rubio;C. Kolakofsky;V. M. Hill;Donald F. Summers
与VSV核糖核蛋白复合物迅速相关的蛋白质被发现是L，NS和N;这种关联使得新生的复制RNA分子对RNA酶具有抗性。用放线菌酮处理VSV感染的细胞，并检查与RNP相关的蛋白质，结果表明，有一个L、NS和N的池，可能允许复制在蛋白质合成停止后继续约20分钟。
The proteins rapidly associated with VSV ribonucleoprotein complexes were found to be L, NS, and N; this association rendered nascent replicating RNA molecules resistant to RNase. Treatment of VSV-infected cells with cycloheximide and examination of the proteins associated with the RNPs showed that there was a pool of L, NS, and N that perhaps allowed replication to continue for approximately 20 min after cessation of protein synthesis.