Preliminary evidence of behavioral and cognitive sequelae of obstructive sleep apnea in children
Preliminary evidence of behavioral and cognitive sequelae of obstructive sleep apnea in children
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DOI：
10.1016/s1389-9457(01)00070-3
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发表时间：
2002-01-01
期刊：
影响因子：
4.8
通讯作者：
Dahl, Ronald E.
中科院分区：
文献类型：
--
作者：
Lewin, Daniel S.;Rosen, Raymond C.;Dahl, Ronald E.
目的：探讨儿童阻塞性睡眠呼吸暂停（OSA）的日间后遗症。背景：阻塞性睡眠呼吸暂停综合征是儿童中一种常见疾病，估计患病率在1.1 - 2.9%之间。尽管只有少数初步研究描述了阻塞性睡眠呼吸暂停症儿童的这些问题，但许多研究已经证实了成人阻塞性睡眠呼吸暂停症患者的神经心理缺陷。方法：在本研究中，健康的OSA患儿（n = 28）和年龄匹配的健康对照组（n = 10）采用睡眠、行为和认知功能的标准测量进行评估。结果：OSA患儿的行为问题发生率明显高于健康对照组（F = 7.29, P < 0.005）。诊断为中度至重度OSA的儿童在评估持续注意力的定时取消任务上得分明显较低（F = 10.0, P < 0.01）。阻塞性睡眠呼吸暂停严重程度（rho = -86, P < 0.01）与语言能力之间存在显著相关性。结论：这些初步发现表明，儿童阻塞性睡眠呼吸暂停存在可识别的日间后遗症，评估这些日间干扰对确定干预措施很重要。(C) 2002 Elsevier Science B.V.版权所有
Objectives: To characterize the daytime sequelae of obstructive sleep apnea (OSA) in children.Background: OSA syndrome is a common disorder in children with estimates of prevalence ranging from 1.1 to 2.9%. Numerous studies have documented neuropsychological deficits in adults with OSA, although only a few preliminary studies have described these problems in children with OSA.Methods: In the present study, otherwise healthy children with OSA (n = 28), and a healthy age-matched comparison group (n = 10) were assessed with standard measures of sleep, behavior, and cognitive function.Results: Children with OSA had significantly more behavior problems than the healthy comparison group based on parents' reports (F = 7.29, P < 0.005). Children diagnosed with moderate to severe OSA had significantly lower scores on a timed cancellation task that assesses sustained attention (F = 10.0, P < 0.01). A significant association was found between OSA severity (rho = -86, P < 0.01) and measures of verbal ability.Conclusions: These initial findings suggest that there are identifiable daytime sequelae of childhood OSA and that it is important to evaluate these daytime disturbances in making determinations about intervention. (C) 2002 Elsevier Science B.V. All rights reserved.