EFFECTS OF EXERCISE ON AORTIC INPUT IMPEDANCE AND PRESSURE WAVE FORMS IN NORMAL HUMANS
EFFECTS OF EXERCISE ON AORTIC INPUT IMPEDANCE AND PRESSURE WAVE FORMS IN NORMAL HUMANS
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DOI：
10.1161/01.res.48.3.334
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发表时间：
1981-01-01
影响因子：
20.1
通讯作者：
ALTOBELLI, SA
中科院分区：
文献类型：
--
作者：
MURGO, JP;WESTERHOF, N;ALTOBELLI, SA
为研究仰卧自行车运动对无心血管疾病的13例男性受试者的升主动脉输入阻抗的影响，采用多传感器心导管同时记录升主动脉流速和压力，并在同一位置安装电磁流速探头和压力传感器。导管头端的第二个压力传感器提供左心室压力。Fick心输出量用于将速度信号缩放为瞬时体积流量。输入阻抗由主动脉压力和流量的10个谐波计算。对于每名受试者，对休息和运动期间最少15次心跳的阻抗模量和相位进行平均。外周阻力从静息值1142 ± 0.01降低。51（.+-. SE）dyn s/cm 5至712 . ±. 39 dyn s/cm5。特性阻抗保持不变，静止值为47 ± 1.5。4dyn s/cm 5和45 ± 1的运动值。4 dyn s/cm 5。结果与主动脉压增加（96 . ±. 2到111 .+-. 2 mm Hg）和脉搏波速度，这意味着主动脉顺应性降低。主动脉横截面积的增加明显抵消了顺应性和脉搏波速度的这些变化的影响，从而导致特征阻抗不变。脉搏波速度的增加导致波反射在运动过程中发生更早，但压力波形状的一般特征保持不变。
The effects of supine bicycle exercise on the input impedance of the ascending aorta were studied in 13 male subjects undergoing cardiac catheterization, but in whom no cardiovascular disease was found. Ascending aortic flow velocity and pressure were recorded simultaneously from a multisensor catheter with an electromagnetic flow velocity probe and a pressure sensor mounted at the same location. A 2nd pressure sensor at the catheter tip provided left ventricular pressure. Fick cardiac outputs were used to scale the velocity signal to instantaneous volumetric flow. Input impedance was calculated from 10 harmonics of aortic pressure and flow. For each subject, impedance moduli and phases from a minimum of 15 beats during rest and exercise were averaged. Peripheral resistance decreased from a resting value of 1142 .+-. 51 (.+-. SE) dyn s/cm5 to 712 .+-. 39 dyn s/cm5 during exercise. Characteristic impedance remained unchanged with a resting value of 47 .+-. 4 dyn s/cm5 and an exercise value of 45 .+-. 4 dyn s/cm5. The results were associated with an increase in aortic pressure (96 .+-. 2 to 111 .+-. 2 mm Hg) and pulse wave velocity implying a decrease in aortic compliance. An increase in aortic cross-sectional area apparently offsets the effects of these changes in compliance and pulse wave velocity to result in an unchanged characteristic impedance. The increase in pulse wave velocity caused wave reflections to occur earlier during exercise, but the general characteristics of the pressure wave shapes remained unchanged.