Microglia: an active player in the regulation of synaptic activity.
Microglia: an active player in the regulation of synaptic activity.
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DOI：
10.1155/2013/627325
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发表时间：
2013
影响因子：
3.1
通讯作者：
Tsirka SE
中科院分区：
文献类型：
--
作者：
Ji K;Miyauchi J;Tsirka SE
突触可塑性对于发育和发达的大脑中的加工和适应至关重要。众所周知，星形胶质细胞在维持所谓的“三重突触”中起着重要作用。越来越多的证据表明，第四种细胞类型，小胶质细胞，对这种维持也至关重要。小胶质细胞是中枢神经系统（CNS）的常驻巨噬细胞。由于其良好的炎症功能，研究主要集中在其先天免疫特性。小胶质细胞在发育和稳态中维持突触的作用还没有很好的定义。一些重要的发现揭示了小胶质细胞在突触中的关键作用。越来越清楚的是，小胶质细胞在适当的突触发育和消除中发挥着重要作用。
Synaptic plasticity is critical for elaboration and adaptation in the developing and developed brain. It is well established that astrocytes play an important role in the maintenance of what has been dubbed “the tripartite synapse”. Increasing evidence shows that a fourth cell type, microglia, is critical to this maintenance as well. Microglia are the resident macrophages of the central nervous system (CNS). Because of their well-characterized inflammatory functions, research has primarily focused on their innate immune properties. The role of microglia in the maintenance of synapses in development and in homeostasis is not as well defined. A number of significant findings have shed light on the critical role of microglia at the synapse. It is becoming increasingly clear that microglia play a seminal role in proper synaptic development and elimination.
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DOI：
10.1083/jcb.201007161
发表时间：
2011-02-21
期刊：
The Journal of cell biology
影响因子：
--
作者：
Gauthier-Kemper A;Weissmann C;Golovyashkina N;Sebö-Lemke Z;Drewes G;Gerke V;Heinisch JJ;Brandt R
通讯作者：
Brandt R
影响因子：
4.7
作者：
Garg, S;Syed, MM;Kielian, T
通讯作者：
Kielian, T
小胶质细胞形态和动态行为受离子型谷氨酸能和GABA能神经传递的调节。
影响因子：
3.7
作者：
Fontainhas AM;Wang M;Liang KJ;Chen S;Mettu P;Damani M;Fariss RN;Li W;Wong WT
通讯作者：
Wong WT
影响因子：
56.9
作者：
Beattie, EC;Stellwagen, D;Malenka, RC
通讯作者：
Malenka, RC
影响因子：
11.4
作者：
Bianco, Fabio;Perrotta, Cristiana;Novellino, Luisa;Francolini, Maura;Riganti, Loredana;Menna, Elisabetta;Saglietti, Laura;Schuchman, Edward H.;Furlan, Roberto;Clementi, Emilio;Matteoli, Michela;Verderio, Claudia
通讯作者：
Verderio, Claudia