Evaluation of serum levels of cathepsin S among colorectal cancer patients.
Evaluation of serum levels of cathepsin S among colorectal cancer patients.
复制标题
结直肠癌患者血清组织蛋白酶S水平的评价。
DOI：
10.1016/j.amsu.2022.103831
复制
发表时间：
2022-06
影响因子：
1.7
通讯作者：
Anbari, Khatereh
中科院分区：
文献类型：
--
作者：
Ghanadi, Koroush;Ashorzadeh, Saber;Aliyepoor, Asghar;Anbari, Khatereh
结直肠癌是全球第三大常见癌症。组织蛋白酶是已知参与癌症进展和转移的蛋白酶。本研究的目的是评价血清组织蛋白酶S在癌症患者和对照组的水平及其对预后的影响。在这项病例对照研究中，纳入了转诊至我们胃肠科门诊的结直肠癌患者。对照组由健康人组成。分析这些患者的组织蛋白酶S水平，并记录由人口统计学数据、癌症分期、结肠镜检查结果、CEA标记物和组织蛋白酶S水平组成的检查表。在纳入研究的80例患者和健康对照中，两组之间的年龄、性别和BMI无显著差异，分别为p = 0.265、p = 0.752和p = 0.2。组织蛋白酶S水平显著高于住院患者组p < 0.001，并且与肿瘤的分期显著相关。CEA标志物与组织蛋白酶S水平的升高也呈线性相关，p < 0.001。结论：组织蛋白酶S在大肠癌患者中升高，可作为大肠癌预后的一个重要指标。结直肠癌是全球第三大常见癌症。组织蛋白酶是已知参与癌症进展和转移的蛋白酶。组织蛋白酶S在结直肠癌患者中表达显著，与预后不良相关。
Colorectal cancer is the third most common cancer worldwide. Cathepsins are protease that are known to be involved in cancer progression and metastasis. The aim of this study is to evaluate the levels of serum cathepsin S in patients and control subjects and its effects on the prognosis of the cancer. In this case-control study, colorectal cancer patients referred to our gastroenterology clinic were included. The control group consisted of healthy individuals. Cathepsin S levels were analyzed in these patients and the check list consisting of demographic data, cancer stage, colonoscopy findings, CEA marker and cathepsin S levels were recorded. Of 80 patients and healthy controls included in the study, age, gender and BMI were not significantly different among the two groups, p = 0.265, p = 0.752 and p = 0.2, respectively. Cathepsin S levels were significantly greater in-patient group p < 0.001 and was significantly correlated with the stage of the tumor. CEA marker was also linear related with the increased levels of cathepsin S, p < 0.001. Our study concluded that cathepsin S is elevated in the cancer patients and can be a significant marker for the prognosis of colorectal cancer. Colorectal cancer is the third most common cancer worldwide. Cathepsins are protease that are known to be involved in cancer progression and metastasis. Cathepsin S is significantly in colorectal cancer patients and is associated with poor prognosis.