Influence of image registration on apparent diffusion coefficient images computed from free-breathing diffusion MR images of the abdomen
Influence of image registration on apparent diffusion coefficient images computed from free-breathing diffusion MR images of the abdomen
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DOI：
10.1002/jmri.24792
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发表时间：
2015-08-01
影响因子：
4.4
通讯作者：
Klein, Stefan
中科院分区：
文献类型：
--
作者：
Guyader, Jean-Marie;Bernardin, Livia;Klein, Stefan
BackgroundTo评估图像配准对表观扩散系数（ADC）图像的影响，从腹部自由呼吸弥散加权磁共振图像（DW-MRIs）。MethodsA综合管道的基础上自动三维非刚性图像配准开发，以补偿错位DW-MRI数据集从五个健康受试者扫描两次。在每个图像内以及在时间序列中的图像之间校正运动。在两个腹部感兴趣体积（VOI）中比较配准和未配准的ADC分布。插值和高斯模糊作为替代策略，以减少运动artifactions.ResultsAmong四个考虑的情况下（没有处理，插值，模糊和注册），注册产生最好的对齐分数的影响。中位ADC根据所选方案而异：对于所考虑的数据集，未经处理获得的ADC比注册高30%。配准提高了体素再现性至少2倍，并降低了不确定性（Frechet-Cramer-Rao下限）。注册提供了类似的改进，在再现性和不确定性，作为收购四倍以上data.ConclusionPatient运动在图像采集过程中导致错位DW-MRI和不准确的ADC，这可以使用自动注册来解决。J.磁共振Imaging 2015;42：315-330.
BackgroundTo evaluate the influence of image registration on apparent diffusion coefficient (ADC) images obtained from abdominal free-breathing diffusion-weighted MR images (DW-MRIs).MethodsA comprehensive pipeline based on automatic three-dimensional nonrigid image registrations is developed to compensate for misalignments in DW-MRI datasets obtained from five healthy subjects scanned twice. Motion is corrected both within each image and between images in a time series. ADC distributions are compared with and without registration in two abdominal volumes of interest (VOIs). The effects of interpolations and Gaussian blurring as alternative strategies to reduce motion artifacts are also investigated.ResultsAmong the four considered scenarios (no processing, interpolation, blurring and registration), registration yields the best alignment scores. Median ADCs vary according to the chosen scenario: for the considered datasets, ADCs obtained without processing are 30% higher than with registration. Registration improves voxelwise reproducibility at least by a factor of 2 and decreases uncertainty (Frechet-Cramer-Rao lower bound). Registration provides similar improvements in reproducibility and uncertainty as acquiring four times more data.ConclusionPatient motion during image acquisition leads to misaligned DW-MRIs and inaccurate ADCs, which can be addressed using automatic registration. J. Magn. Reson. Imaging 2015;42:315-330.