Mood Differences Among Parkinson's Disease Patients With Mild Cognitive Impairment
Mood Differences Among Parkinson's Disease Patients With Mild Cognitive Impairment
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DOI：
10.1176/appi.neuropsych.15090221
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发表时间：
2016-06-01
影响因子：
2.9
通讯作者：
Bowers, Dawn
中科院分区：
文献类型：
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作者：
Jones, Jacob D.;Mangal, Paul;Bowers, Dawn
对健康老年人的研究表明，在轻度认知障碍（MCI）患者中，冷漠、抑郁和焦虑更为常见。本研究考察了伴有和不伴有轻度认知障碍的帕金森病患者的情绪/动机症状的差异。PD患者（N= 214）接受神经认知评估，包括冷漠量表（apathy Scale）、抑郁量表（Beck抑郁量表- ii）和特质焦虑量表（State-Trait anxiety Inventory trait Scale）。PD合并轻度认知障碍患者的特质焦虑和抑郁更为严重。将MCI划分为遗忘型和非遗忘型亚型，结果显示，与认知完整的PD患者相比，遗忘型MCI患者的抑郁、冷漠和焦虑程度更高。与认知完整的PD患者相比，PD和MCI患者报告的情绪症状更大。
Studies with healthy elderly adults suggest that apathy, depression, and anxiety are more common among individuals with mild cognitive impairment (MCI). This study examined differences in mood/amotivational symptoms among patients with Parkinson's disease (PD) with and without MCI. Patients with PD (N= 214) underwent neurocognitive evaluations including assessment of apathy (Apathy Scale), depression (Beck Depression Inventory-II), and trait anxiety (State-Trait Anxiety Inventory trait scale). Trait anxiety and depression were more severe in patients with PD with MCI. Delineation of MCI into amnestic and nonamnestic subtypes revealed greater depression, apathy, and anxiety among patients with PD with amnestic MCI relative to cognitively intact patients with PD. Patients with PD and MCI report greater mood symptoms compared to patients with PD who are cognitively intact.