Choline ameliorates cardiovascular damage by improving vagal activity and inhibiting the inflammatory response in spontaneously hypertensive rats.
Choline ameliorates cardiovascular damage by improving vagal activity and inhibiting the inflammatory response in spontaneously hypertensive rats.
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胆碱通过改善自发性高血压大鼠迷走神经活动和抑制炎症反应来改善心血管损伤
DOI：
10.1038/srep42553
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发表时间：
2017-02-22
影响因子：
4.6
通讯作者：
Zang W
中科院分区：
文献类型：
--
作者：
Liu L;Lu Y;Bi X;Xu M;Yu X;Xue R;He X;Zang W
自主神经功能障碍和免疫异常会导致全身炎症反应，从而导致高血压时的心血管损害。本报告的目的是探讨胆碱对高血压患者心血管损害的影响。将8周龄雄性自发性高血压大鼠(SHR)和Wistar-京都大鼠按8 /(kg·d)剂量分别腹腔注射胆碱或赋形剂。8周后，胆碱可恢复SHR的心功能，表现为心率、收缩压、左心室收缩压下降，射血分数和短轴缩短率增加。胆碱还可改善SHR的心肌肥厚，表现为左室内径减小和心肌细胞横截面积减小。此外，胆碱还能改善SHR的肠系膜动脉功能，保护血管内皮细胞超微结构。值得注意的是，胆碱的保护作用可能是由于其抗炎作用。胆碱可下调SHR肠系膜动脉IL-6和肿瘤坏死因子-α的表达，上调IL-10的表达，这可能与其抑制Toll样受体4有关。此外，胆碱还能恢复SHR的压力感受性反射敏感性和血清乙酰胆碱水平，提示胆碱可改善迷走神经活动。本研究提示胆碱具有心血管保护作用，可作为高血压的一种潜在的辅助治疗方法。
Autonomic dysfunction and abnormal immunity lead to systemic inflammatory responses, which result in cardiovascular damage in hypertension. The aim of this report was to investigate the effects of choline on cardiovascular damage in hypertension. Eight-week-old male spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats were intraperitoneally injected with choline or vehicle (8 mg/kg/day). After 8 weeks, choline restored the cardiac function of the SHRs, as evidenced by decreased heart rate, systolic blood pressure, left ventricle systolic pressure, and ±dp/dtmaxand increased ejection fraction and fractional shortening. Choline also ameliorated the cardiac hypertrophy of the SHRs, as indicated by reduced left ventricle internal dimensions and decreased cardiomyocyte cross-sectional area. Moreover, choline improved mesenteric arterial function and preserved endothelial ultrastructure in the SHRs. Notably, the protective effect of choline may be due to its anti-inflammatory effect. Choline downregulated expression of interleukin (IL)-6 and tumour necrosis factor-α and upregulated IL-10 in the mesenteric arteries of SHRs, possibly because of the inhibition of Toll-like receptor 4. Furthermore, choline restored baroreflex sensitivity and serum acetylcholine level in SHRs, thus indicating that choline improved vagal activity. This study suggests that choline elicits cardiovascular protective effects and may be useful as a potential adjunct therapeutic approach for hypertension.