Dengue: knowledge gaps, unmet needs, and research priorities.
Dengue: knowledge gaps, unmet needs, and research priorities.
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DOI：
10.1016/s1473-3099(16)30473-x
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Harris E
中科院分区：
文献类型：
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作者：
Katzelnick LC;Coloma J;Harris E
登革病毒（DENV）是一种由蚊子传播的病原体，每年导致多达约1亿例登革热病例，给众多中低收入国家带来了重大的公共卫生、社会和经济负担。科学家、疫苗研发人员以及受影响的社区所取得的重大进展揭示了新的见解，并使登革热预防和控制有了新的干预措施和方法。此类研究凸显了关于对登革热的基本认识以及开发新工具的努力的更多问题。我们讨论了中低收入国家现有的登革热诊断、疾病预后、监测和病媒控制方法，以及引入疫苗的潜在后果。我们还总结了目前关于登革热流行病学、免疫学和发病机制的知识以及近期的见解，及其对理解自然感染以及当前和未来疫苗的影响。
Dengue virus (DENV) is a mosquito-borne pathogen that causes up to ~100 million dengue cases each year, placing a major public health, social and economic burden on numerous low- and middle-income countries (LMICs). Major advances by scientists, vaccine developers, and affected communities are revealing new insights and enabling novel interventions and approaches to dengue prevention and control. Such research has highlighted further questions about both the basic understanding of dengue and efforts to develop new tools. We discuss existing approaches to dengue diagnostics, disease prognosis, surveillance, and vector control in LMICs as well as potential consequences of vaccine introduction. We also summarize current knowledge and recent insights into dengue epidemiology, immunology, and pathogenesis, and their implications for understanding natural infection and current and future vaccines.