Transcranial magnetic stimulation reduces pain in patients with major depression a sham-controlled study
Transcranial magnetic stimulation reduces pain in patients with major depression a sham-controlled study
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DOI：
10.1097/nmd.0b013e31802f58d1
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发表时间：
2007-05-01
影响因子：
1.9
通讯作者：
Roy-Byrne, Peter
中科院分区：
文献类型：
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作者：
Avery, David H.;Holtzheimer, Paul E., III;Roy-Byrne, Peter
本研究评估了接受经颅磁刺激（TMS）与假刺激相比，耐药型抑郁症患者报告疼痛的变化。在这项研究中，68名患有重度抑郁症的受试者被随机分配到TMS或假刺激组。以10 Hz的频率在5秒的列车中以估计的前额叶皮层阈值的110%将重复TMS传递到左背外侧前额叶皮层。使用肌肉、骨骼和关节疼痛的治疗后效应系统评估（SAFTEE）项目，在治疗前、治疗期间和治疗后评估疼痛水平。与假手术组相比，研究期间TMS与SAFTEE疼痛项目显著（p < 0.05）减少相关。疼痛的减轻不能用抗抑郁作用来解释。
This study evaluated the change in reported pain in patients with medication-resistant major depression receiving transcranial magnetic stimulation (TMS) compared with sham stimulation. In this study, 68 subjects with major depression were randomized to either TMS or sham stimulation. Repetitive TMS was delivered to the left dorsolateral prefrontal cortex at a frequency of 10 Hz in 5-second trains at 110% of the estimated preftontal cortex threshold. The level of pain was assessed before, during, and after treatment using the Systematic Assessment for Treatment Emergent Effects (SAFTEE) item for pain in the muscles, bones, and joints. Compared with sham, TMS was associated with a significant (p < 0.05) reduction in the SAFTEE pain item during the study. The reduction in pain could not be explained by the antidepressant effects.