Statins reduce spirochetal burden and modulate immune responses in the C3H/HeN mouse model of Lyme disease.
Statins reduce spirochetal burden and modulate immune responses in the C3H/HeN mouse model of Lyme disease.
复制标题
他汀类药物减轻了螺旋体负担，并调节莱姆病的C3H/Hen小鼠模型中的免疫反应。
DOI：
10.1016/j.micinf.2016.03.004
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发表时间：
2016-06
影响因子：
5.8
通讯作者：
Seshu J
中科院分区：
文献类型：
--
作者：
Van Laar TA;Hole C;Rajasekhar Karna SL;Miller CL;Reddick R;Wormley FL;Seshu J
莱姆病是由伯氏疏螺旋体引起的一种全身性疾病。莱姆螺旋体编码一个功能性的3-羟基-3-甲基戊二酰辅酶A还原酶(HMGR EC 1.1.1.88)，它是甲氧戊酸途径的限速酶，对细胞壁生物发生至关重要。他汀类药物在体外对伯氏杆菌有抑制作用。使用莱姆病的小鼠模型，我们发现他汀类药物有助于减少细菌负担，改变小鼠的免疫反应，有利于螺旋体的清除。
Lyme disease (LD) is a systemic disorder caused by Borrelia burgdorferi. Lyme spirochetes encode for a functional 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGR EC 1.1.1.88) serving as a rate limiting enzyme of the mevalonate pathway that contribute to components critical for cell wall biogenesis. Statins have been shown to inhibit B. burgdorferi in vitro. Using a mouse model of Lyme disease, we found that statins contribute to reducing bacterial burden and altering the murine immune response to favor clearance of spirochetes.