Two-Year Body Composition Analyses of Long-Lived GHR Null Mice
Two-Year Body Composition Analyses of Long-Lived GHR Null Mice
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DOI：
10.1093/gerona/glp175
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发表时间：
2010-01-01
影响因子：
5.1
通讯作者：
Kopchick, John J.
中科院分区：
文献类型：
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作者：
Berryman, Darlene E.;List, Edward O.;Kopchick, John J.
生长激素受体基因破坏（GHR-/-）小鼠表现出寿命延长和脂肪组织质量增加。尽管这种肥胖表型在年轻成年雄性GHR-/-小鼠中已被广泛报道，但缺乏雌性和其他年龄的任何性别的数据。因此，本研究的目的是纵向评估雄性和雌性GHR-/-小鼠的身体组成。结果显示，GHR-/-小鼠具有更大的脂肪量百分比，在整个生命中绝对脂肪量没有显著差异。瘦体重显示出相反的趋势，基因型之间的瘦体重百分比没有显著差异，但GHR-/-小鼠的绝对体重降低。雄性小鼠的身体组成差异比雌性小鼠更明显，GHR-/-小鼠的两种性别均显示出皮下脂肪库的特定增大。沿着先前发表的数据，这些结果表明皮下区域过量脂肪具有一致且有趣的保护作用。
Growth hormone receptor gene-disrupted (GHR-/-) mice exhibit increased life span and adipose tissue mass. Although this obese phenotype has been reported extensively for young adult male GHR-/- mice, data for females and for other ages in either gender are lacking. Thus, the purpose of this study was to evaluate body composition longitudinally in both male and female GHR-/- mice. Results show that GHR-/- mice have a greater percent fat mass with no significant difference in absolute fat mass throughout life. Lean mass shows an opposite trend with percent lean mass not significantly different between genotypes but absolute mass reduced in GHR-/- mice. Differences in body composition are more pronounced in male than in female mice, and both genders of GHR-/- mice show specific enlargement of the subcutaneous adipose depot. Along with previously published data, these results suggest a consistent and intriguing protective effect of excess fat mass in the subcutaneous region.