Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study
Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study
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DOI：
10.1371/journal.pntd.0008280
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发表时间：
2020-05-01
影响因子：
3.8
通讯作者：
Wu, Chao
中科院分区：
文献类型：
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作者：
Huang, Rui;Zhu, Li;Wu, Chao
武汉以外地区2019冠状病毒病（COVID-19）患者的临床特征数据有限。本研究旨在描述中国江苏省COVID-19的临床特征，并确定COVID-19重症的危险因素。回顾性收集了来自中国江苏省8个城市的8家医院的住院COVID-19患者的临床数据。描述了COVID-19患者的临床表现，并分析了COVID-19重症的风险因素。截至2020年2月10日，共招募了202名住院的COVID-19患者。患者的中位年龄为44.0岁（四分位距，33.0-54.0）。55例（27.2%）患者有合并症。发病时常见症状为发热（156例[77.2%]）和咳嗽（120例[59.4%]）。淋巴细胞减少66例（32.7%）。193例（95.5%）患者有异常影像学表现。11例（5.4%）患者入住重症监护室，无患者死亡。23例（11.4%）患者患有严重疾病。COVID-19的严重疾病与体重指数（BMI）独立相关。28 kg/m2（比值比[OR]，9.219; 95%置信区间[CI]，2.731至31.126; P
Limited data are available for clinical characteristics of patients with coronavirus disease 2019 (COVID-19) outside Wuhan. This study aimed to describe the clinical characteristics of COVID-19 and identify the risk factors for severe illness of COVID-19 in Jiangsu province, China. Clinical data of hospitalized COVID-19 patients were retrospectively collected in 8 hospitals from 8 cities of Jiangsu province, China. Clinical findings of COVID-19 patients were described and risk factors for severe illness of COVID-19 were analyzed. By Feb 10, 2020, 202 hospitalized patients with COVID-19 were enrolled. The median age of patients was 44.0 years (interquartile range, 33.0-54.0). 55 (27.2%) patients had comorbidities. At the onset of illness, the common symptoms were fever (156 [77.2%]) and cough (120 [59.4%]). 66 (32.7%) patients had lymphopenia. 193 (95.5%) patients had abnormal radiological findings. 11 (5.4%) patients were admitted to the intensive care unit and none of the patients died. 23 (11.4%) patients had severe illness. Severe illness of COVID-19 was independently associated with body mass index (BMI). 28 kg/m(2) (odds ratio [OR], 9.219; 95% confidence interval [CI], 2.731 to 31.126; P