Scintigraphic in vivo assessment of the development of pulmonary intravascular macrophages in liver disease: experimental study in rats with biliary cirrhosis.
Scintigraphic in vivo assessment of the development of pulmonary intravascular macrophages in liver disease: experimental study in rats with biliary cirrhosis.
复制标题
肝脏疾病中肺血管内巨噬细胞发育的闪烁显像体内评估：胆汁性肝硬化大鼠的实验研究。
DOI：
10.1378/chest.120.3.941
复制
发表时间：
2001
期刊：
影响因子：
9.6
通讯作者：
A. L. Pape
中科院分区：
文献类型：
--
作者：
Elisabeth Miot;Laurence Faure;Yves Guichard;Jérôme Montharu;A. L. Pape
研究目标
STUDY OBJECTIVES
In regard to nuclear medicine literature reporting lung uptake of colloidal radiopharmaceuticals in patients with liver diseases, it has been hypothesized that liver abnormalities could trigger induction of pulmonary intravascular macrophages (PIMs) in humans normally lacking them. Recently, experimental induction of PIMs in rats in which they are not normally prevalent has been demonstrated to be at the origin of pulmonary hemodynamic alterations with an increased susceptibility to ARDS. If such induction may occur in humans, the risk of pulmonary hemodynamic alterations has to be considered and detected. This study demonstrates in a rodent model of biliary cirrhosis that scintigraphy of phagocytic function as commonly used for liver exploration is a suitable strategy for staging PIM development.
DESIGN
Sixty rats were randomized as follows: bile duct section (n = 40), sham operation (n = 10), and no operation (n = 10). The rats were submitted to scintigraphy of phagocytic function every 5 days over 35 days for the assessment of radiocolloid uptake within lung and liver. At day 35, radioactivity of blood was counted and immunohistochemistry was performed on lung specimens.
RESULTS
As disease progressed, radiopharmaceutical uptake decreased within the liver, while increasing considerably in the lung. At day 35, lung uptake averaged about 66% as compared to 3% before surgery. Lung histologic findings revealed numerous intravascular mononuclear cells closely related to the monocyte-macrophage lineage.
CONCLUSION
Scintigraphy of phagocytic function commonly used for liver scanning could be a suitable strategy for the diagnosis of the induction of PIMs under pathologic situations.
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影响因子：
15.9
作者：
CHANG, SW;OHARA, N
通讯作者：
OHARA, N
DOI：
10.1152/ajplung.1999.276.1.l146
发表时间：
1999-01-01
影响因子：
4.9
作者：
Brain, JD;Molina, RM;Warner, AE
通讯作者：
Warner, AE
肺部清除循环内毒素会导致绵羊急性肺损伤。
DOI：
--
发表时间：
1988
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Warner,AE;DeCampJr,MM;Molina,RM;Brain,JD
通讯作者：
Brain,JD
DOI：
--
发表时间：
1986
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Warner,AE;Barry,BE;Brain,JD
通讯作者：
Brain,JD
绵羊肺血管内巨噬细胞和脂质体的血流动力学效应。
DOI：
10.1152/jappl.1988.64.3.1143
发表时间：
1988
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Miyamoto,K;Schultz,E;Heath,T;Mitchell,MD;Albertine,KH;Staub,NC
通讯作者：
Staub,NC