Short ischemia causes endothelial dysfunction in porcine coronary vessels in an in vivo model
Short ischemia causes endothelial dysfunction in porcine coronary vessels in an in vivo model
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DOI：
10.1016/s0003-4975(00)02253-0
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发表时间：
2001-01-01
影响因子：
4.6
通讯作者：
Franco-Cereceda, A
中科院分区：
文献类型：
--
作者：
Lockowandt, U;Liska, J;Franco-Cereceda, A
背景本研究旨在评价短时间缺血（10 min）和长时间缺血（60 min）再灌注对乙酰胆碱（ACh）、腺苷（ADO）和内皮素（ET）引起的冠状动脉血流变化的影响。将麻醉猪的冠状动脉左前降支闭塞10或60分钟，然后再灌注120分钟。观察冠状动脉内灌注ACh、ADO和ET后左前降支血流动力学的变化。短期缺血（10分钟）引起血管舒张功能下降，但不引起血管收缩反应。长时间缺血（60分钟）可使ADO引起的血管舒张作用减弱，并使ET引起的血管收缩作用加重。目前的研究结果表明，短时间的缺血（10分钟）导致冠状动脉血管张力的内皮调节紊乱，这种内皮调节更敏感，缺血和再灌注后血管平滑肌功能的变化之前。(Ann Thorac Surg 2001;71：265-9）（C）2001年，胸外科医师协会。
Background. The aim of this study was to evaluate the effects of a short period of ischemia (10 mins) and a prolonged period of ischemia (60 mins) followed by reperfusion on coronary flow changes induced by acetylcholine (ACh), adenosine (ADO), and endothelin (ET).Methods. The left anterior descending coronary artery in anesthetized pigs was occluded for 10 or 60 minutes followed by 120 minutes reperfusion. Thereafter, the now changes in the left anterior descending coronary artery were studied after intracoronary infusion of ACh, ADO, and ET.Results. Short-term ischemia (10 minutes) caused a decrease in vasodilatation, but not the vasoconstriction response to ACh. Prolonged ischemia (60 minutes) impaired ADO induced vasodilatation and aggravated ET evoked vasoconstriction.Conclusions. The present findings suggest that a short period of ischemia (10 minutes) causes disturbances of the endothelial regulation of coronary vascular tone and that this endothelial regulation is more sensitive, and precedes changes in vascular smooth muscle function after ischemia and reperfusion. (Ann Thorac Surg 2001;71:265-9) (C) 2001 by the Society of Thoracic Surgeons.