A Metal-Free Oxidative Amination of Benzoxazoles with Primary Amines and Ammonia
A Metal-Free Oxidative Amination of Benzoxazoles with Primary Amines and Ammonia
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DOI：
10.1055/s-0031-1289902
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发表时间：
2012-01-01
期刊：
影响因子：
2
通讯作者：
Nachtsheim, Boris J.
中科院分区：
文献类型：
--
作者：
Kloeckner, Ulrich;Weckenmann, Nicole M.;Nachtsheim, Boris J.
用伯胺直接氧化胺化非官能化苯并恶唑，有效地合成了2-氨基苯并恶唑。该反应可以在没有过渡金属的情况下进行，使用催化量的碘化季铵和过氧化叔丁基作为廉价且易于处理的共氧化剂。除伯胺外，还利用NH3水溶液在杂环核心中引入了一个伯胺基团。
An efficient synthesis of 2-aminobenzoxazoles is described by a direct oxidative amination of unfunctionalized benzoxazoles with primary amines. The reaction could be performed in the absence of transition metals by using catalytic amounts of a quaternary ammonium iodide and tert-butylhydroperoxide as a cheap and easy-to-handle co-oxidant. In addition to primary amines, aqueous solutions of NH3 were used to introduce a primary amine group into the heterocyclic core.