Arterial wall thickening and stiffening in children and adolescents with type 1 diabetes
Arterial wall thickening and stiffening in children and adolescents with type 1 diabetes
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DOI：
10.1016/j.diabres.2006.03.004
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发表时间：
2006-10-01
影响因子：
5.1
通讯作者：
Baykara, Murat
中科院分区：
文献类型：
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作者：
Atabek, Mehmet Emre;Kurtoglu, Selim;Baykara, Murat
目的：我们评估了颈总动脉（CCA）的结构和功能特征，这是早期颈动脉粥样硬化的标志，并研究了它们与 1 型糖尿病儿童和青少年代谢和人体测量参数的关系。 材料和方法：对 45 名 I 型糖尿病患者和 33 名对照者进行了非侵入性超声测量。患者和对照组之间的年龄、性别和体重指数相匹配。我们研究了 CCA 的内膜中层厚度 (IMT)、顺应性、扩张性、舒张期壁应力 (DWS) 和增量弹性模量 (IEM)。评估代谢和人体测量参数，如血脂、血浆糖化血红蛋白、体重指数、腰臀比和血压。结果：糖尿病患者的 CCA-IMT 显着高于对照组（0.48 +/- 0.06 mm 对比 0.33 +/- 0.07 mm；p < 0.001）。糖尿病儿童的 DWS 值显着高于对照组（1.18 +/- 0.29 mmHg x 102 对比 0.81 +/- 0.25 mmHg x 10(2)；p < 0.001），IEM 值显着高于对照组（1.26 +/- 0.57 mmHg x 10(3) 对比 0.77 +/- 0.28 mmHg x 10(3)；P < 0.001）。患者和对照组之间的动脉顺应性和扩张性差异不显着 (p > 0.05)。在所有受试者的多变量回归模型中，糖尿病状态是 IMT (p < 0.001)、DWS (p < 0.001) 和 IEM (p = 0.001) 的最佳预测因子。 结论：我们的结果表明，患有 I 型糖尿病的儿童和青少年患者与 CCA 结构和功能的早期损伤有关，并且糖尿病状态可能是 CCA 壁硬化和增厚的主要危险因素，这作为发生的早期事件而受到相当大的关注。动脉粥样硬化。 (c) 2006 Elsevier Ireland Ltd. 保留所有权利。
Objective: We evaluated structural and functional characteristics of the common carotid artery (CCA), a marker of early carotid atherosclerosis, and investigated their relation to metabolic and anthropometric parameters in children and adolescents with type 1 diabetes.Materials and methods: Non-invasive ultrasonographic measurements were made in 45 type I diabetic patients and 33 controls. Age, sex, and body mass index were matched between patients and controls. We investigated intima-media thickness (IMT), compliance, distensibility, diastolic wall stress (DWS) and incremental elastic modulus (IEM) of the CCA. Metabolic and anthropometric parameters such as serum lipids, plasma glycated haemoglobin, body mass index, waist-hip ratio and blood pressure were assessed.Results: The diabetic patients had significantly higher CCA-IMT than the controls (0.48 +/- 0.06 mm versus 0.33 +/- 0.07 mm; p < 0.001). The diabetic children had significantly higher values than the controls for DWS (1.18 +/- 0.29 mmHg x 102 versus 0.81 +/- 0.25 mmHg x 10(2); p < 0.001) and for IEM (1.26 +/- 0.57 mmHg x 10(3) versus 0.77 +/- 0.28 mmHg x 10(3); P < 0.001). The difference was not significant between patients and controls for arterial compliance and for distensibility (p > 0.05). In a multivariate regression model for all subjects, diabetic state was the best predictor of IMT (p < 0.001), DWS (p < 0.001) and IEM (p = 0.001).Conclusion: Our results suggested that children and adolescent patients with type I diabetes are associated with early impairment of CCA structure and function and that diabetic state may be the main risk factor for CCA wall stiffening and thickening, which are of considerable concern as possible early events in the genesis of atheroma. (c) 2006 Elsevier Ireland Ltd. All rights reserved.