Some Subtle Lessons from the Calyx of Held Synapse.
Some Subtle Lessons from the Calyx of Held Synapse.
复制标题
从持有突触的花萼中进行了一些微妙的教训。
DOI：
10.1016/j.bpj.2016.12.017
复制
发表时间：
2017-01-24
影响因子：
3.4
通讯作者：
Neher E
中科院分区：
文献类型：
--
作者：
Neher E
Held的萼是一个巨大的神经末梢，在听觉通路中形成一个突触。由于它的大尺寸，它提供了许多生物物理学研究的优势，包括电压钳前和突触后室和负载与指示剂染料和笼化合物。最近的研究结果在这里的花萼三个方面进行了审查，其中每一个似乎只有微妙的后果神经诱发的兴奋性突触后电流：囊泡异质性，耐火性的释放网站，和超启动。总之，他们确定短期的可塑性功能，表面上类似于一个简单的囊泡池模型的预期。然而，这些方面的详细考虑可能需要正确的机械解释的数据与正常和扰动功能的突触，以及建模的动态短期可塑性。
The calyx of Held is a giant nerve terminal that forms a glutamatergic synapse in the auditory pathway. Due to its large size, it offers a number of advantages for biophysical studies, including voltage-clamp of both pre- and postsynaptic compartments and the loading with indicator dyes and caged compounds. Three aspects of recent findings on the calyx are reviewed here, each of which seems to have only subtle consequences for nerve-evoked excitatory postsynaptic currents: vesicle heterogeneity, refractoriness of release sites, and superpriming. Together, they determine short-term plasticity features that are superficially similar to those expected for a simple vesicle pool model. However, detailed consideration of these aspects may be required for the correct mechanistic interpretation of data from synapses with normal and perturbed function, as well as for modeling the dynamics of short-term plasticity.