ISLET FUNCTION IN OFFSPRING OF MOTHERS ON LOW-PROTEIN DIET DURING GESTATION
ISLET FUNCTION IN OFFSPRING OF MOTHERS ON LOW-PROTEIN DIET DURING GESTATION
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DOI：
10.2337/diab.40.2.s115
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发表时间：
1991-12-01
期刊：
影响因子：
7.7
通讯作者：
HOET, JJ
中科院分区：
文献类型：
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作者：
DAHRI, S;SNOECK, A;HOET, JJ
怀孕期间给予低蛋白饮食（8%对20%）会影响后代内分泌胰腺的结构和功能。 在妊娠21.5天，我们报告了细胞增殖、胰岛大小、胰岛血管化和胰腺胰岛素含量的减少。 在这项研究中，我们证明了在体外用精氨酸和亮氨酸等氨基酸刺激时，这些胎儿胰岛的胰岛素分泌受损。 如果后代在哺乳期、断奶期和成年期都保持相同的低蛋白饮食，那么在血糖水平正常的情况下，空腹胰岛素水平仍然很低。 70天时的葡萄糖耐量受损，胰岛素反应较低。 此外，永久性功能损伤似乎是由子宫内低蛋白饮食诱导的，因为从出生到成年的正常饮食在葡萄糖挑战后不能恢复正常的胰岛素反应。 我们的实验结果强调了均衡饮食与定性和定量氨基酸组成的影响，胎儿内分泌胰腺正常发育，而不会在成年后产生持久的功能和结构后果。
A low-protein diet (8 vs. 20%) administered during pregnancy affects the structure and function of the endocrine pancreas of the offspring. At 21.5 days of gestation, we reported a reduction of cell proliferation, islet size, islet vascularization, and pancreatic insulin content. In this study, we demonstrated an impairment of insulin secretion of these fetal islets when stimulated in vitro with amino acids such as arginine and leucine. If the offspring is kept on the same low-protein diet during suckling, weaning, and adulthood, fasting insulin levels remain low in the presence of normal blood glucose levels. Glucose tolerance at 70 days is impaired, with lower insulin response. In addition, permanent functional damage seems to be induced in utero by a low-protein diet, because a normal diet given from birth to adulthood does not restore normal insulin response after a glucose challenge. Our experimental results stress the impact of a balanced diet with qualitative and quantitative amino acid composition for the fetal endocrine pancreas to develop normally, without lasting functional and structural consequences in adulthood.