The catalytic ortho-arylation of tyrosine
The catalytic ortho-arylation of tyrosine
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DOI：
10.1039/b906119c
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发表时间：
2009-01-01
影响因子：
3.2
通讯作者：
Mitchell, Charlotte J.
中科院分区：
文献类型：
--
作者：
Bedford, Robin B.;Haddow, Mairi F.;Mitchell, Charlotte J.
研究了铑催化的外消旋2-叔丁基酪氨酸直接邻位芳基化反应。随后除去叔丁基得到2-芳基化酪氨酸，其可以在6位进一步进行铑基芳基化。在一种情况下，通过二芳基化物质的进一步芳基化形成的产物被分离。
The rhodium-catalysed direct ortho-arylation of protected racemic 2-tert-butyl tyrosine has been developed. The subsequent removal of the tert-butyl group yields the 2-arylated tyrosine which can undergo further rhodium-based arylation at the 6-position. In one instance a product formed by further arylation of the diarylated species was isolated.