Gastrointestinal bleeding with severe mucosal involvement in a patient with generalized pustular psoriasis without IL36RN mutation.
Gastrointestinal bleeding with severe mucosal involvement in a patient with generalized pustular psoriasis without IL36RN mutation.
复制标题
无 IL36RN 突变的全身性脓疱型银屑病患者出现胃肠道出血并伴有严重粘膜受累。
DOI：
10.1111/1346-8138.14711
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Tada Y.
中科院分区：
文献类型：
--
作者：
Komatsuda S;Kamata M;Chijiwa C;Namiki K;Fukaya S;Hayashi K;Fukuyasu A;Tanaka T;Ishikawa T;Ohnishi T;Abe K;Yamamoto T;Aozasa N;Sugiura K;Tada Y.
泛发性脓疱性银屑病（GPP）是一种全身性炎症性疾病，表现为红斑和无菌脓疱，病理特征为Kogoj海绵状脓疱。GPP有时伴有黏膜受累，最常见的病变位于舌部，IL 36 RN突变与GPP的发病有关，尤其是在无寻常型银屑病病史的GPP患者中。IL 36RN突变与GPP粘膜受累的关系存在争议。我们在此报告了一例60岁男性GPP患者，既往无斑块状银屑病病史，不仅表现为严重的皮肤病变和关节炎，还表现为咽部和胃肠道病变的严重粘膜受累，导致胃肠道出血。我们的病例在IL 36RN基因上没有任何突变。我们应该知道，严重的GPP可能会导致消化道出血。IL 36RN突变与GPP中粘膜受累的相关性仍有待阐明。
Generalized pustular psoriasis (GPP) is a systemic inflammatory disease that presents with erythema and sterile pustules, pathologically characterized by Kogoj's spongiform pustules. GPP is sometimes accompanied by mucosal involvement, and the most common lesion is on the tongue.IL36RNmutation was found to contribute to the pathogenesis of GPP especially in patients who develop GPP without a past medical history of psoriasis vulgaris. The association ofIL36RNmutation with mucosal involvement in GPP is controversial. We herein report a 60‐year‐old male GPP patient with no past history of plaque psoriasis presenting with not only severe skin lesions and arthritis but also severe mucosal involvements of pharyngeal and gastrointestinal lesions, which led to gastrointestinal bleeding. Our case did not have any mutation in theIL36RNgene. We should be aware that severe GPP can cause gastrointestinal bleeding. The relevancy ofIL36RNmutation with mucosal involvement in GPP remains to be elucidated.