Relationship between Neurocognition and Regional Brain Volumes in Traumatized Adolescents with and without Posttraumatic Stress Disorder
Relationship between Neurocognition and Regional Brain Volumes in Traumatized Adolescents with and without Posttraumatic Stress Disorder
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DOI：
10.1159/000339558
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发表时间：
2012-01-01
影响因子：
3.2
通讯作者：
Seedat, Soraya
中科院分区：
文献类型：
--
作者：
Ahmed, Fatima;Spottiswoode, Bruce S.;Seedat, Soraya
目的：应用收敛神经认知和结构成像范式研究青少年创伤后应激障碍（PTSD）的研究是有限的；在当前的研究中，我们使用基于体素的形态测量法（VBM）来获得组间的体积差异，并使用Freesurfer来检查认知和区域脑体积之间的关系。方法：参与者为21名创伤后应激障碍青少年和32名创伤后应激障碍青少年。在1.5特斯拉MAGNETOM Siemens Symphony扫描仪上获得磁共振图像。然后使用在FSL上实施的VBM来比较组间灰质体积，之后使用Freesurfer来获得不同脑区域的整体体积和厚度测量。结果：在注意、延迟回忆和视觉重建测试中，两组间存在显著的神经认知差异。在VBM上，PTSD组在左脑岛、右楔前叶和右扣带回三个区域发现灰质减少，使用未校正的值（p < 0.001），而在初始Freesurfer流上没有发现组间统计学差异。Freesurfer对Qdec的进一步分析显示，PTSD组的脑岛显著减少。此外，在Freesurfer分析中，胼胝体和脑岛的体积变化与逻辑记忆和视觉再现的缺陷显著相关。结论：创伤暴露本身可能足以引起青少年的结构变化，而与PTSD的发展无关。巴塞尔S. Karger股份有限公司版权所有
Objectives: Studies using convergent neurocognitive and structural imaging paradigms in adolescent posttraumatic stress disorder (PTSD) are limited; in the current study we used both voxel-based morphometry (VBM) to obtain between-group volumetric differences, and Freesurfer to examine the relationship between cognition and regional brain volumes. Methods: Participants were 21 traumatized adolescents with PTSD matched with 32 traumatized adolescents without PTSD. Magnetic resonance images were obtained on a 1.5-Tesla MAGNETOM Siemens Symphony scanner. VBM implemented on FSL was then used to compare between-group grey matter volumes, after which Freesurfer was used to obtain global volume and thickness measurements in different brain regions. Results: Significant between-group neurocognitive differences were found for tests of attention, delayed recall and visual reconstruction. On VBM, reduced grey matter was found in three regions in the PTSD group: left insula, right precuneus and right cingulate gyrus, using uncorrected values (p < 0.001), while no statistically significant between-group differences were found on the initial Freesurfer stream. Further Freesurfer analysis on Qdec revealed significant reductions in the insula for the PTSD group. In addition, volumetric changes in the corpus callosum and insula were significantly associated with deficits in logical memory and visual reproduction on Freesurfer analysis. Conclusions: Trauma exposure of itself may be sufficient to cause structural changes in adolescents regardless of PTSD development. Copyright (C) 2012 S. Karger AG, Basel