Respiratory adenoviral infections in children: A study of hospitalized cases in southern Taiwan in 2001-2002
Respiratory adenoviral infections in children: A study of hospitalized cases in southern Taiwan in 2001-2002
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DOI：
10.1093/tropej/50.5.279
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发表时间：
2004-10-01
影响因子：
2
通讯作者：
Jong, YJ
中科院分区：
文献类型：
--
作者：
Chen, HL;Chiou, SS;Jong, YJ
腺病毒占儿童呼吸道疾病的5- 10%。本研究以2001年1月至2002年12月在高雄市小康医院儿科住院的4333名儿童为研究对象，分析其急性呼吸道感染的临床特征及发病频率。从317例患者中分离出腺病毒，分离率为7.67%。对186例标本采用聚合酶链反应（PCR）和/或PCR-限制性片段长度多态性（PCR- rflp）进行血清型分析。2001年，发现腺病毒4型占多数（57%），其次是1.5.6%型（15%）、2型（13%）、14型（8%）、3型（5%）和7型（2%）。2002年，3型成为主要类型（46%），而以前占主导地位的4型减少到6%，7型从2%增加到19%。症状和体征包括发烧（98.7%）、咳嗽（77.6%）、异常呼吸声（噼啪声和/或喘息声）23.3%、腹痛（18.9%）、呕吐（21.8%）和腹泻（25.2%）。平均发热时间4.8天（0 ~ 19天）。在分析了186例血清型的病例中，咽炎和扁桃体炎（47.8%）是最常见的表现，其次是肺炎（25.2%）、支气管炎（12.9%）和咽结膜热（7.6%）。4 ~ 8岁儿童是呼吸道腺病毒感染的最常见人群。我们的病人预后都很好。本研究为南台儿童呼吸道腺病毒感染的临床鉴别诊断及治疗提供资讯。
Adenoviruses account for 5-10 per cent of respiratory illnesses in children. To analyse the clinical features and the temporal frequency in acute adenoviral respiratory infections in hospitalized children in southern Taiwan, a total of 4333 children who were admitted to the Department of Pediatrics, Kaohsiung Municipal Hsiaokang (KMHK) Hospital, with clinical evidences of acute respiratory infections between January 2001 and December 2002 were studied. Adenoviruses were isolated from 317 patients with an isolation rate of 7.67 per cent. Serotype analysis was performed by polymerase chain reaction (PCR) and/or PCR-restriction fragment length polymorphism (PCR-RFLP) in 186 specimens. In 2001, adenovirus type 4 was found in the majority (57 per cent), followed by type 1.5.6 (15 per cent), type 2 (13 per cent), type 14 (8 per cent), type 3 (5 per cent), and type 7 (2 per cent). In 2002, type 3 became the major type (46 per cent), whereas the previously predominant type 4 decreased to 6 per cent, and type 7 increased from 2 to 19 per cent. The symptoms and signs included fever (98.7 per cent), cough (77.6 per cent), abnormal breathing sounds (crackles and/or wheezing 23.3 per cent), abdominal pain (18.9 per cent), vomiting (21.8 per cent), and diarrhea (25.2 per cent). The mean duration of fever was 4.8 days (range 0-19 days). In the 186 cases in whom serotypes were analysed, pharyngitis and tonsillitis (47.8 per cent) were the most common presentation, followed by pneumonia (25.2 per cent), bronchitis (12.9 per cent), and pharyngoconjunctival fever (PCF) (7.6 per cent). Children between 4 and 8 years old were the most common group of patients with respiratory adenoviral infections. Our patients all had good prognosis. This adenoviruses molecular epidemiological study provides information that helps physicians in clinical differential diagnosis and treatment of respiratory adenoviral infection in children in southern Taiwan.