Extensive vasogenic edema of anti-aquaporin-4 antibody-related brain lesions
Extensive vasogenic edema of anti-aquaporin-4 antibody-related brain lesions
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DOI：
10.1177/1352458509106613
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发表时间：
2009-09-01
影响因子：
5.8
通讯作者：
Kira, J.
中科院分区：
文献类型：
--
作者：
Matsushita, T.;Isobe, N.;Kira, J.
目的对5例抗水通道蛋白4(AQP4)抗体阳性的视神经脊髓炎谱系障碍患者的脑部广泛病变进行神经影像分析。结果脑部广泛病变3例累及脑白质，1例累及基底节和穹隆。4例患者在表观弥散系数图上表现为高弥散率，3例患者在H-1磁共振波谱上表现为胆碱/肌酸比值升高，N-乙酰天冬氨酸/肌酸比值降低。这些结果表明，病变是与炎症相关的血管源性水肿。与此类病变相关的异常脑症状包括反复发作的边缘脑炎、帕金森综合征和COM。结论抗AQP4抗体与血管源性水肿的神经影像表现有关。多发性硬化症2009；15：1113-1117。Http://msj.sagepub.com
Objective Using neuroimaging, we analyzed the nature of extensive brain lesions in five anti-aquaporin-4 (AQP4) antibody-positive patients with neuromyelitis optica spectrum disorders.Results Extensive brain lesions involved white matter in three, and basal ganglia and corpus callosum in one each. Four patients showed high diffusivity on apparent diffusion coefficient maps and three demonstrated increased choline/creatine ratios and decreased N-acetyl-aspartate/creatine ratios on H-1-magnetic resonance spectroscopy. These findings suggested that the lesions were vasogenic edema associated with inflammation. Unusual brain symptoms associated with such lesions included recurrent limbic encephalitis, parkinsonism, and coma.Conclusion Anti-AQP4 antibody is considered to be associated with the neuroimaging appearances of vasogenic edema. Multiple Sclerosis 2009; 15: 1113-1117. http://msj.sagepub.com