Ecotoxicological effects and mechanism of CuO nanoparticles to individual organisms
Ecotoxicological effects and mechanism of CuO nanoparticles to individual organisms
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纳米氧化铜对个体生物体的生态毒理学效应及机制
DOI：
10.1016/j.envpol.2016.11.066
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发表时间：
2017-02-01
影响因子：
8.9
通讯作者：
Wang, Xiangke
中科院分区：
文献类型：
--
作者：
Hou, Jing;Wang, Xiangxue;Wang, Xiangke
氧化铜纳米颗粒（CuO NPs）广泛用于各种应用，例如抗菌剂、光催化剂和气体传感器。CuO纳米颗粒的扩大生产和广泛使用可能对个体生物和生态系统构成风险。全面了解纳米氧化铜的环境危害及其机理，对于评估纳米氧化铜的环境风险，促进纳米氧化铜的安全应用具有重要意义。然而，氧化铜纳米颗粒对生物个体的毒性作用及其作用机制仍然缺乏和模糊。为保证纳米氧化铜的安全使用，应关注纳米氧化铜在低浓度下的长期和慢性效应。应致力于开发区分CuO纳米颗粒和溶解态Cu2+的毒性的技术，并通过控制粒径、修饰表面特性、选择合适的暴露途径和调节Cu2+从CuO纳米颗粒中的释放来降低CuO纳米颗粒的毒性。本文综述了CuO纳米颗粒对不同生物类群（微生物、藻类、植物、无脊椎动物和脊椎动物）的毒性，并讨论了其潜在的毒性机制，包括氧化应激、动态失衡和协同效应。(C)2016爱思唯尔有限公司版权所有
Copper oxide nanoparticles (CuO NPs) are used extensively in a variety of applications such as antimicrobial agent, photo-catalyst and gas sensors. The expanding production and widespread utilization of CuO NPs may pose risks to individual organisms and ecosystem. Comprehensive understanding the CuO NPs-induced adverse effects and their underlying mechanism are of great importance to assess the environmental risk of CuO NPs and to expand their use safely. However, toxic effects of CuO NPs to individual organisms and the mechanism of their action are still deficient and ambiguities. To ensure the safely use of CuO NPs, more attention should be paid on the long-term and chronic effects of CuO NPs at low concentration. Efforts should be devoted to develop techniques to differentiate toxicities induced by CuO NPs or dissolved Cu2+, and to reduce the toxicity of CuO NPs by controlling the particle diameter, modifying surface characteristic, selecting proper exposure route and regulating the release of Cu2+ from CuO NPs. This review provides a brief overview of toxicity of CuO NPs to individual organisms with a broad range of taxa (microorganisms, algae, plants, invertebrates and vertebrates) and to discuss the underlying toxicity mechanisms including oxidative stress, dynamic unbalance and coordination effects. (C) 2016 Elsevier Ltd. All rights reserved.