Control of cell migration through mRNA localization and local translation.
Control of cell migration through mRNA localization and local translation.
复制标题
DOI：
10.1002/wrna.1265
复制
发表时间：
2015-01
影响因子：
7.3
通讯作者：
Liu, Gang
中科院分区：
文献类型：
--
作者：
Liao, Guoning;Mingle, Lisa;Van de Water, Livingston;Liu, Gang
细胞迁移在发育、伤口愈合、免疫防御和肿瘤转移等许多正常和病理功能中发挥着重要作用。极化迁移细胞表现出许多细胞骨架蛋白的不对称分布，这被认为对于建立和维持细胞极性和定向细胞迁移至关重要。为了将这些蛋白质定位到功能位点，细胞使用多种机制，例如蛋白质转运和 mRNA 定位介导的局部蛋白质合成。与前者被深入研究和相对充分理解相比，后者研究不足且相对较少理解。然而，mRNA定位和局部翻译研究的最新进展表明，mRNA定位和局部翻译是蛋白质定位的特定且有效的方式，并且对于胚胎发育、神经元功能和许多其他细胞过程至关重要。关于发育和其他细胞过程中 mRNA 的定位、运输和翻译，有很多精彩的评论。本综述将重点关注 mRNA 定位介导的局部蛋白质生物合成及其对体细胞迁移的影响。
Cell migration plays an important role in many normal and pathological functions such as development, wound healing, immune defense and tumor metastasis. Polarized migrating cells exhibit asymmetric distribution of many cytoskeletal proteins which is believed to be critical for establishing and maintaining cell polarity and directional cell migration. To target these proteins to the site of function, cells use a variety of mechanisms such as protein transport and mRNA localization-mediated local protein synthesis. In contrast to the former which is intensively investigated and relatively well understood, the latter has been under-studied and relatively poorly understood. However, recent advances in the study of mRNA localization and local translation have demonstrated that mRNA localization and local translation are specific and effective ways for protein localization and are crucial for embryo development, neuronal function and many other cellular processes. There are excellent reviews on mRNA localization, transport and translation during development and other cellular processes. This review will focus on mRNA localization-mediated local protein biogenesis and its impact on somatic cell migration.
登录
查看更多内容
影响因子：
3.2
作者：
Arjonen, Antti;Kaukonen, Riina;Ivaska, Johanna
通讯作者：
Ivaska, Johanna
影响因子：
3.3
作者：
Chang, P;Torres, J;King, ML
通讯作者：
King, ML
影响因子：
64.8
作者：
Chicurel, ME;Singer, RH;Ingber, DE
通讯作者：
Ingber, DE
影响因子：
8
作者：
Bell, Jessica L.;Waechter, Kristin;Muehleck, Britta;Pazaitis, Nikolaos;Koehn, Marcel;Lederer, Marcell;Huettelmaier, Stefan
通讯作者：
Huettelmaier, Stefan
影响因子：
9.8
作者：
Cui XA;Zhang H;Palazzo AF
通讯作者：
Palazzo AF