EXTRA-UTERINE FATTY-ACID ACCRETION IN INFANT BRAIN - IMPLICATIONS FOR FATTY-ACID REQUIREMENTS
EXTRA-UTERINE FATTY-ACID ACCRETION IN INFANT BRAIN - IMPLICATIONS FOR FATTY-ACID REQUIREMENTS
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DOI：
10.1016/0378-3782(80)90016-x
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发表时间：
1980-01-01
影响因子：
2.5
通讯作者：
CHANCE, GW
中科院分区：
文献类型：
--
作者：
CLANDININ, MT;CHAPPELL, JE;CHANCE, GW
测定婴儿脑的总脂肪酸含量，以评估出生后前13周脑组织中结构脂质合成的最低脂肪酸需求。脂肪酸的增长率测定回归分析的组织脂肪成分在不同的出生后年龄。定量脂肪酸分析表明，出生后小脑，额叶和枕叶的长链多烯脂肪酸的增长最初似乎落后于脑重量和脑脂肪含量的增加速度。4周后，总长链脂肪酸以与脑重增加相似的速率增加。小脑中单个脂肪酸的增加也反映了组织脂肪酸含量的变化。全脑和小脑脂肪酸成分的这些发育变化与估计人类新生儿的最小子宫外脂肪酸需求量定量相关。
Total fatty acid content of infant brain was determined to assess minimal fatty acid requirements for synthesis of structural lipids in brain tissue during the first 13 wk of life. Fatty acid accretion rates were determined by regression analysis of tissue fat components at varying postnatal ages. Quantitative fatty acid analysis indicated that postnatal accretion of long-chain polyenoic fatty acids in cerebellum, frontal and occipital brain lobes initially appeared to lag behind the rate of increase in brain weight and brain fat content. After a 4 wk period total long-chain fatty acids increased at a rate similar to the increase in brain weight. Accretion of individual fatty acids in cerebellum also reflected changes in tissue fatty acid content. These developmental changes in fatty acid components of whole brain and cerebellum are quantitatively relevant to estimation of the minimal extrauterine fatty acid requirements of the human neonate.