Divide, multitask, and conquer: Coordination in channel regulation.
Divide, multitask, and conquer: Coordination in channel regulation.
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分而治之：渠道监管的协调。
DOI：
10.1080/19336950.2017.1292814
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Pitt,GeoffreyS
中科院分区：
文献类型：
--
作者：
Pablo,JuanLorenzo;Pitt,GeoffreyS
神经元的基本功能是以动作电位（神经元膜电压的快速变化）的形式传递信息。离子通道通过利用跨神经元膜的离子梯度来产生和维持动作电位。神经元表达多种离子通道，其调节和亚细胞定位对神经元功能具有重要影响。在过去的一年中，我们描述了神经元中成纤维细胞生长因子同源因子（FHF）介导的两种离子通道调节模式。 1、2FHF (FGF11-FGF14) 是成纤维细胞生长因子 (FGF) 家族的成员，但其功能与经典 FGF 不同。 3 与经典 FGF 相比，FHF 与电压门控钠通道 (VGSC) 相互作用并改变 VGSC 行为。 4 先前的研究暗示，特定 FHF 影响特定 VGSC 的方式因细胞类型和所查询的特定 FHF-VGSC 对而异，但尚未检查同一神经元内不同 FHF 的个体作用。 5
A neuron’s essential function is to relay information in the form of the action potential, a rapid change in the neuronal membrane voltage. Ion channels generate and maintain action potentials by harnessing the ionic gradients across neuronal membranes. Neurons express a wide array of ion channels whose regulation and subcellular localization have important consequences for neuronal function. In the past year, we described 2 modes of ion channel regulation mediated by fibroblast growth factor homologous factors (FHFs) in neurons. 1, 2FHFs (FGF11-FGF14) are members of the fibroblast growth factor (FGF) family but function differently than canonical FGFs. 3 FHFs, in contrast to canonical FGFs, interact with voltage-gated sodium channels (VGSCs) and modify VGSC behavior. 4 Previous studies hinted that the ways in which particular FHFs affected specific VGSCs vary depending on cell type and the particular FHF-VGSC pair queried, but individual roles for distinct FHFs within the same neuron had not been examined. 5