The Ontario Neurodegenerative Disease Research Initiative (ONDRI)
The Ontario Neurodegenerative Disease Research Initiative (ONDRI)
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DOI：
10.1017/cjn.2016.415
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发表时间：
2017-03-01
影响因子：
3
通讯作者：
Strong, Michael J.
中科院分区：
文献类型：
--
作者：
Farhan, Sali M. K.;Bartha, Robert;Strong, Michael J.
由于个体发展为神经退行性或神经血管疾病的表现，因此需要开发可靠的方法来识别它们。我们正在进行一项观察性研究（安大略神经退行性疾病研究计划[ONDRI]），包括基因组学、神经成像和认知评估以及语言、言语、步态、视网膜成像和眼动追踪。研究的疾病包括阿尔茨海默病、肌萎缩侧索硬化、额颞叶痴呆、帕金森病和血管性认知障碍。来自ONDRI的数据将被收集到Brain-CODE数据库中，以促进相关分析。ONDRI将提供一个内表型个体的库，这将是一个独特的，公开可用的资源。
Because individuals develop dementia as a manifestation of neurodegenerative or neurovascular disorder, there is a need to develop reliable approaches to their identification. We are undertaking an observational study (Ontario Neurodegenerative Disease Research Initiative [ONDRI]) that includes genomics, neuroimaging, and assessments of cognition as well as language, speech, gait, retinal imaging, and eye tracking. Disorders studied include Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, and vascular cognitive impairment. Data from ONDRI will be collected into the Brain-CODE database to facilitate correlative analysis. ONDRI will provide a repertoire of endophenotyped individuals that will be a unique, publicly available resource.