Cumulative menstrual months and breast cancer risk by hormone receptor status and ethnicity: The Breast Cancer Etiology in Minorities Study.
Cumulative menstrual months and breast cancer risk by hormone receptor status and ethnicity: The Breast Cancer Etiology in Minorities Study.
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按激素受体状态和种族划分的累积月经月数和乳腺癌风险：少数民族乳腺癌病因学研究。
DOI：
10.1002/ijc.33791
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发表时间：
2022
影响因子：
6.4
通讯作者：
Wu,AnnaH
中科院分区：
文献类型：
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作者：
Cole,SarahE;John,EstherM;Hines,LisaM;Phipps,AmandaI;Koo,Jocelyn;Ingles,SueA;Baumgartner,KathyB;Slattery,MarthaL;McKean-Cowden,Roberta;Wu,AnnaH
生殖和激素因素可能通过内源性雌激素暴露影响乳腺癌风险。累积月经月数 (CMM) 可以用作这种暴露的替代衡量标准。使用四项基于人群的乳腺癌研究（7284 例病例和 7242 例对照）的统一数据，我们使用逻辑回归分析了 CMM 与乳腺癌风险之间的种族特异性关联，并调整了绝经状态和其他风险因素。无论绝经状态如何，较高的 CMM 与非西班牙裔白人、西班牙裔和亚裔美国人的乳腺癌风险增加相关（所有 FDR 调整后的 Ptrends = .0004），但在非裔美国人中则不然。在绝经前非裔美国人中，存在 CMM 越高风险越低的暗示趋势。按绝经前非洲裔美国女性的体重指数 (BMI) 进行分层显示，非肥胖 (BMI <30kg/m2) 女性与 CMM 呈非显着正相关，而肥胖女性则呈显着负相关（OR 每 50 CMM = 0.56，95% CI 0.37‐0.87，Ptrend= .03）。激素受体阳性（HR+；ER+ 或 PR+）乳腺癌的风险模式相似；除非洲裔美国人外，所有绝经前和绝经后种族群体都发现呈正相关。 HR−（ER− 和 PR−）乳腺癌在所有组中均不与 CMM 相关，但绝经前亚裔美国人之间存在提示性正相关（OR 每 50 个 CMM = 1.33，P= .07）。总之，这些结果增加了越来越多的证据表明，与其他族裔群体相比，已确定的生殖和激素因素对非裔美国女性乳腺癌风险的影响不同，对 HR- 乳腺癌的影响也与 HR+ 乳腺癌不同。
Reproductive and hormonal factors may influence breast cancer risk via endogenous estrogen exposure. Cumulative menstrual months (CMM) can be used as a surrogate measure of this exposure. Using harmonized data from four population‐based breast cancer studies (7284 cases and 7242 controls), we examined ethnicity‐specific associations between CMM and breast cancer risk using logistic regression, adjusting for menopausal status and other risk factors. Higher CMM was associated with increased breast cancer risk in non‐Hispanic Whites, Hispanics and Asian Americans regardless of menopausal status (all FDR adjustedPtrends = .0004), but not in African Americans. In premenopausal African Americans, there was a suggestive trend of lower risk with higher CMM. Stratification by body mass index (BMI) among premenopausal African American women showed a nonsignificant positive association with CMM in nonobese (BMI <30 kg/m2) women and a significant inverse association in obese women (OR per 50 CMM = 0.56, 95% CI 0.37‐0.87,Ptrend= .03). Risk patterns were similar for hormone receptor positive (HR+; ER+ or PR+) breast cancer; a positive association was found in all premenopausal and postmenopausal ethnic groups except in African Americans. HR− (ER− and PR−) breast cancer was not associated with CMM in all groups combined, except for a suggestive positive association among premenopausal Asian Americans (OR per 50 CMM = 1.33,P= .07). In summary, these results add to the accumulating evidence that established reproductive and hormonal factors impact breast cancer risk differently in African American women compared to other ethnic groups, and also differently for HR− breast cancer than HR+ breast cancer.