CEREBRAL, CEREBELLAR, AND BRAIN STEM GANGLIOSIDES IN MICE SUSCEPTIBLE TO AUDIOGENIC SEIZURES
CEREBRAL, CEREBELLAR, AND BRAIN STEM GANGLIOSIDES IN MICE SUSCEPTIBLE TO AUDIOGENIC SEIZURES
复制标题
易发声性癫痫发作的小鼠的大脑、小脑和脑干神经节苷脂
作者：
T. Seyfried;G. Glaser;R. Yu
摘要：研究了 21 日龄的听源性癫痫发作抗性 (C57BL/6J) 和易感性 (DBA/2J) 小鼠的大脑、小脑和脑干中神经节苷脂的定量和定性分布。与 C57 小鼠中的浓度相比，DBA 大脑和脑干中的神经节苷脂浓度（μg/单位重量）较高，但 DBA 小脑中的浓度较低。一般来说，DBA小鼠的脑含水量低于C57小鼠。研究发现，两种菌株之间多种神经节苷脂的分布存在差异，并且在三个大脑区域中差异往往沿同一方向。在菌株之间观察到的神经节苷脂模式最一致和显着的差异是 DBA 大脑的所有三个区域中 GM1 浓度较高。这些结果表明 DBA 小鼠比 C57 小鼠具有更重的有髓鞘 CNS。讨论了这些观察结果与固有的听源性癫痫易感性的关系。
Abstract— The quantitative and qualitative distribution of gangliosides was investigated in the cerebrum, cerebellum and brain stem of audiogenic seizure resistant (C57BL/6J) and susceptible (DBA/2J) mice at 21 days of age. The concentration of gangliosides (μg/unit weight) was higher in the DBA cerebrum and brain stem, but lower in the DBA cerebellum compared to the concentration in C57 mice. In general, the brain water content was lower in DBA mice than in C57 mice. The distributions of a number of gangliosides were found to be different between the two strains and the differences were often in the same direction across the three brain regions. The most consistant and significant difference in ganglioside pattern observed between the strains was the higher concentration of GM1 in all three regions of the DBA brain. These results suggest that DBA mice have a more heavily myelinated CNS than C57 mice. The relationship of these observations to inherent audiogenic seizure susceptibility is discussed.