The effects of dexamethasone on experimental brain tumors: I. Transcapillary transport and blood flow in RG-2 rat gliomas.
The effects of dexamethasone on experimental brain tumors: I. Transcapillary transport and blood flow in RG-2 rat gliomas.
复制标题
地塞米松对实验性脑肿瘤的影响：I. RG-2 大鼠神经胶质瘤中的毛细血管转运和血流。
DOI：
10.1007/bf01054719
复制
发表时间：
1995
影响因子：
3.9
通讯作者：
Groothuis,DR
中科院分区：
文献类型：
--
作者：
Molnar,P;Lapin,GD;Groothuis,DR
Dexamethasone dramatically improves cerebral edema associated with malignant gliomas. Although the pathophysiology of this effect is not clearly understood, many investigators have postulated that tumor capillary permeability is reduced by dexamethasone. We studied blood-to-tissue transport and blood flow in 178 RG-2 transplanted gliomas in a control group and four groups given dexamethasone at doses of 3, 6, 9, and 12 mg/kg for four days.14C-α aminoisobutyric acid (AIB) was used to study blood-to-tissue transport in 31 animals; in an additional 27 animals14C-AIB and131I-iodoantipyrine (IAP) were used in double label experiments to study blood-to-tissue transport and blood flow. Regional measurements of the transfer constant (K) of AIB and blood flow (F) were made with quantitative autoradiography. There were significant differences between the control and dexamethasone-treated groups with regard to weight loss and plasma glucose. However, there wasnosignificant effect of dexamethasone on values of K or F, regardless of the tumor or brain region examined, and regardless of the dose of dexamethasone administered. Analysis of the profiles of the transfer constant of AIB in the brain around tumor showed that the K of AIB decreased within 0.5 mm of the tumor edge in direct relationship to the dexamethasone dose. These results do not support the hypothesis that dexamethasone reduces brain tumor capillary permeability, and suggest that dexamethasone may decrease tumor-associated cerebral edema by effects on bulk flow away from the tumor margin.
登录
查看更多内容
放射自显影显示下丘脑褪黑素受体位点
影响因子：
2.9
作者：
J. Vanecek;A. Pavlík;H. Illnerová
通讯作者：
H. Illnerová
脊椎动物的昼夜节律和光周期系统：松果体和褪黑激素的作用
影响因子：
3.5
作者：
H. Underwood;B. Goldman
通讯作者：
B. Goldman
影响因子：
56.9
作者：
REPPERT, SM;WEAVER, DR;STOPA, EG
通讯作者：
STOPA, EG
影响因子：
4.8
作者：
ABE, K;ROBISON, GA;BAIRD, CE
通讯作者：
BAIRD, CE
碘化褪黑激素：通过质量和 1 H NMR 光谱进行分子结构的制备和表征。
影响因子：
2.9
作者：
O. Vakkuri;Erkki Lämsä;E. Rahkamaa;H. Ruotsalainen;Juhani Leppäluoto
通讯作者：
Juhani Leppäluoto