Effects of variation in porcine MYOD1 gene on muscle fiber characteristics, lean meat production, and meat quality traits
Effects of variation in porcine MYOD1 gene on muscle fiber characteristics, lean meat production, and meat quality traits
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DOI：
10.1016/j.meatsci.2012.03.018
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发表时间：
2012-09-01
期刊：
影响因子：
7.1
通讯作者：
Hong, K. C.
中科院分区：
文献类型：
--
作者：
Lee, E. A.;Kim, J. M.;Hong, K. C.
利用猪MYOD 1基因的3个单核苷酸多态性（SNPs）进行关联分析和单倍型构建，以评价其取代的效果。使用了403头约克郡和伯克希尔品种的猪。检测MYOD 1的mRNA表达水平。g.489 C>T和g.1264 C>A SNP与几种肌纤维特征、腰部眼面积和亮度显著相关。特别是，具有两个位点的异质基因型的动物在瘦肉产量和肉质性状方面都表现出良好的性能。单倍型替换的结果与单个SNPs的关联相似。此外，2个SNPs对mRNA表达有显著影响。因此，MYOD 1中g.489 C>T和g.1264 C>A SNP可能是一个有意义的DNA标记，可用于猪重要经济性状的改良。(C)2012爱思唯尔有限公司保留所有权利。
Three single nucleotide polymorphisms (SNPs) in the porcine MYOD1 gene were used for association analysis and haplotype construction to evaluate the effects of their substitution. Four hundred and three pigs of Yorkshire and Berkshire breeds were used. The mRNA expression levels of MYOD1 were examined. The g.489 C>T and g.1264 C>A SNPs were significantly associated with several muscle fiber characteristics, the loin eye area, and lightness. Particularly, animals having hetero-genotypes of both sites showed good performance both in lean meat production and meat quality traits. The results of haplotype substitution were similar to the associations of individual SNPs. Moreover, the 2 SNPs had significant effects on mRNA expression. Therefore, the g.489 C>T and g.1264 C>A SNPs in MYOD1 may be meaningful DNA markers that can be used for improving important porcine economic traits. (C) 2012 Elsevier Ltd. All rights reserved.