Patient-specific computational fluid dynamics modeling of anterior communicating artery aneurysms: a study of the sensitivity of intra-aneurysmal flow patterns to flow conditions in the carotid arteries.
Patient-specific computational fluid dynamics modeling of anterior communicating artery aneurysms: a study of the sensitivity of intra-aneurysmal flow patterns to flow conditions in the carotid arteries.
复制标题
DOI：
--
复制
发表时间：
2006-11
期刊：
影响因子：
--
通讯作者：
M. Castro;C. Putman;J. Cebral
中科院分区：
文献类型：
--
作者：
M. Castro;C. Putman;J. Cebral
背景和目的本研究的目的是探讨颈内动脉（ICA）内不同生理血流条件对前交通动脉瘤血流动力学的影响。方法根据双侧三维旋转血管造影图像建立2例脑动脉瘤患者的计算流体力学模型。动脉瘤囊的流动动力学进行了分析的影响下，不等的平均流量，相移，和波形之间的ICA。对每例患者共进行9次模拟;为每种血流条件创建电影流速模拟和非稳态壁面剪切应力（WSS）图。构建动脉瘤选定区域的平均WSS幅度的时间依赖性曲线。结果供血血管的平均血流不平衡倾向于将WSS升高的区域向占主导地位的流入射流移动，并改变WSS峰值的大小。WSS分布和速度模拟的整体定性外观没有受到实质性影响。相位和波形的不对称性增加了血流动力学模式的时间复杂性，并倾向于使流动模式不稳定。结论ICA中相对相位和波形的差异可显著影响血流动力学分布的复杂性和稳定性。这些影响的大小与动脉瘤和供血血管的几何形状有关。应将影响具有1个以上流入通道的脑动脉瘤载瘤动脉中的流动特性的条件纳入流动模型。
BACKGROUND AND PURPOSE The purpose of this study was to investigate the effects of unequal physiologic flow conditions in the internal carotid arteries (ICAs) on the hemodynamics of anterior communicating artery aneurysms. METHODS Patient-specific computational fluid dynamics models of 2 cerebral aneurysms were constructed from bilateral 3D rotational angiograms. The flow dynamics of the aneurysm sac were analyzed under the effect of unequal mean flows, phase shifts, and waveforms between the ICAs. A total of 9 simulations were performed for each patient; cine flow velocity simulations and unsteady wall shear stress (WSS) maps were created for each flow condition. Time-dependent curves of average WSS magnitude over selected regions on the aneurysms were constructed. RESULTS Mean flow unbalances in the feeding vessels tended to shift the regions of elevated WSS towards the dominating inflow jet and to change the magnitude of the WSS peaks. The overall qualitative appearance of the WSS distribution and velocity simulations was not substantially affected. Phase and waveform asymmetry increased the temporal complexity of the hemodynamic patterns and tended to destabilize the flow pattern. CONCLUSIONS Differences in the relative phase and waveform shape in ICAs can significantly affect the complexity and stability of the hemodynamic force distributions. The magnitude of these effects is related to the geometry of the aneurysm and the feeding vessels. Conditions affecting the flow characteristics in the parent arteries of cerebral aneurysms with more than 1 avenue of inflow should be incorporated into flow models.