IL-28, IL-29 and their class II cytokine receptor IL-28R
IL-28, IL-29 and their class II cytokine receptor IL-28R
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DOI：
10.1038/ni873
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发表时间：
2003-01-01
影响因子：
30.5
通讯作者：
Klucher, KM
中科院分区：
文献类型：
--
作者：
Sheppard, P;Kindsvogel, W;Klucher, KM
细胞因子在调节先天性和适应性免疫系统中起关键作用。在这里，我们已经确定了从人类基因组序列的三个细胞因子，命名为白细胞介素28 A（IL-28 A），IL-28 B和IL-29，这是远亲的I型干扰素（IFN）和IL- 10家族。我们发现，像I型IFN，IL- 28和IL- 29由病毒感染诱导，并显示抗病毒活性。然而，IL- 28和IL- 29与由IL-10受体β（IL-10 R β）和孤儿II类受体链（称为IL-28 R α）组成的异二聚体II类细胞因子受体相互作用。这种新描述的细胞因子家族可以作为I型IFN的替代品，提供对病毒感染的免疫力。
Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL- 10 family. We found that like type I IFNs, IL- 28 and IL- 29 were induced by viral infection and showed antiviral activity. However, IL- 28 and IL- 29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection.