Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil
Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil
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DOI：
10.1248/cpb.53.710
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发表时间：
2005-06-01
影响因子：
1.7
通讯作者：
Kadota, S
中科院分区：
文献类型：
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作者：
Awale, S;Kawakami, T;Kadota, S
从巴西 Tabebuia avellanedae 的水提取物中，分离出两种新的环烯醚萜类化合物 (1, 2) 和一种新的苯乙醇苷 (3) 以及十二种已知化合物 (4-15)。它们的结构是根据光谱数据确定的。分离的化合物抑制脂多糖 (LPS) 激活的巨噬细胞样 J774.1 细胞中一氧化氮 (NO) 的产生。化合物1、3、10、11和12显示出比阳性对照N-G-单甲基-L-精氨酸(L-NMMA；IC50，127.4μg/ml)更有效的抑制活性(IC50，13.8-26.1μg/ml)。
From the water extract of Brazilian Tabebuia avellanedae, two new iridoids (1, 2) and a new phenylethanoid glycoside (3) have been isolated together with twelve known compounds (4-15). Their structures were determined based on the spectroscopic data. The isolated compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Compounds 1, 3, 10, 11, and 12 showed inhibitory activities more potent (IC50, 13.8-26.1 mu g/ml) than a positive control N-G-monomethyl-L-arginine (L-NMMA; IC50, 127.4.mu g/ml).