Structural differences between the two human complement C4 isotypes affect the humoral immune response.
Structural differences between the two human complement C4 isotypes affect the humoral immune response.
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DOI：
10.1084/jem.175.2.537
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发表时间：
1992-02-01
期刊：
影响因子：
--
通讯作者：
Carroll MC
中科院分区：
文献类型：
--
作者：
Finco O;Li S;Cuccia M;Rosen FS;Carroll MC
已经使用动物模型来解决人C4的两种同种型之间的已知结构差异的生物学重要性的问题，即，C4 A和C4 B。用人C4 A或C4 B蛋白瞬时重建C4缺陷的豚鼠，并用噬菌体phi X174免疫。本研究的结果表明，C4 A重建动物产生了继发性应答，即，从IgM转换为IgG;而C4 B重组动物则没有。
An animal model has been used to address the question of the biological importance of the known structural difference between the two isotypes of human C4, i.e., C4A and C4B. Guinea pigs deficient in C4 were reconstituted transiently with either human C4A or C4B protein and immunized with the bacteriophage phi X174. Results from this study showed that C4A-reconstituted animals made a secondary response, i.e., switch from IgM to IgG; whereas the C4B-reconstituted animals did not.