EFFECTS OF STARVATION HIGH FAT DIETS AND KETONE INFUSIONS ON URIC ACID BALANCE
EFFECTS OF STARVATION HIGH FAT DIETS AND KETONE INFUSIONS ON URIC ACID BALANCE
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DOI：
10.1016/s0026-0495(65)80039-7
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发表时间：
1965-01-01
期刊：
影响因子：
9.8
通讯作者：
MCPHAUL, JJ
中科院分区：
文献类型：
--
作者：
LECOCQ, FR;MCPHAUL, JJ
对15例患者进行了空腹期间可能影响尿酸排泄的因素研究。补充钾和碱化对禁食期间尿中尿酸排泄的减少没有影响，而苯丙酸和葡萄糖的使用对尿中尿酸的快速排泄有影响。禁食7天后肾小球滤过率没有改变，但尿酸平衡的变化似乎与酮浓度的变化有关。在没有禁食的情况下，通过给6名受试者喂食高脂肪饮食和给5名受试者注射酮来研究酮症的影响。两组尿酸清除率均降低。据推测，酮类与尿酸竞争一个共同的管状分泌部位，酮类变化的幅度妨碍了正常的尿酸分泌。
Studies of factors arising during fasting which could influence uric acid excretion were carried out in 15 patients. Potassium supplementation and alkaliniza-tion did not influence the decreased urinary excretion of uric acid found during fasting, whereas probenecid and glucose administration effected a prompt uricosuria. Glomerular filtration rate was not altered by 7 days of fasting, but changes in uric acid balance appeared related to changes in ketone concentrations. The effect of ketosis in the absence of fasting was studied by feeding high fat diets in 6 subjects and ketone infusions in 5 others. In both groups uric acid clearance was depressed. It is postulated that ketones compete with uric acid for a common tubular secretory site, the magnitude of the changes in ketones precluding normal uric acid secretion.