Ligand exchange based water-soluble, surface-enhanced Raman scattering-tagged gold nanorod probes with improved stability
Ligand exchange based water-soluble, surface-enhanced Raman scattering-tagged gold nanorod probes with improved stability
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基于配体交换的水溶性、表面增强拉曼散射标记金纳米棒探针，具有更高的稳定性
DOI：
10.1016/j.cplett.2011.08.003
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发表时间：
2011-09-15
影响因子：
2.8
通讯作者：
Xiang, Jiannan
中科院分区：
文献类型：
--
作者：
Hu, Jiawen;Lu, Linghui;Xiang, Jiannan
我们报道了表面增强拉曼散射(SERS)标记的金纳米棒(NR)探针的制备。这是通过将初始稳定剂与合成的拉曼活性聚乙二醇(PEG)直接进行配体交换来实现的。用透射电子显微镜、SERS和UV-Vis光谱对SERS标记的Au-NR探针进行了表征。由于Au-NRS的纵向表面等离子体共振与激发波长的耦合，Au-NR探针显示出最佳的表面增强拉曼散射信号。此外，由于外层的聚乙二醇保护层为它们提供了空间稳定性，所以它们在恶劣的条件下是稳定的。这些多功能纳米探针有望在生物分析和生物医学中有广泛的应用。(C)2011爱思唯尔B.V.保留所有权利。
We report the preparation of water-soluble, surface-enhanced Raman scattering (SERS)-tagged Au nanorod (NR) probes. That was accomplished by direct ligand exchange of the initial stabilizer with a synthesized Raman-active poly(ethylene glycol) (PEG). The SERS-tagged Au NR probes were characterized by transmission electron microscopy, SERS, and UV-Vis spectroscopy. The Au NR probes exhibited optimized SERS signals due to the coupling of the longitudinal surface plasmon resonance of the Au NRs with the excitation wavelength. Furthermore, they were stable in adverse conditions because the outer PEG protecting layer provided steric stability to them. These multifunctional nanoprobes are expected to have wide applications in biological analysis and biomedicine. (C) 2011 Elsevier B.V. All rights reserved.