The Role of Psychotropic Medications in the Management of Anorexia Nervosa: Rationale, Evidence and Future Prospects.
The Role of Psychotropic Medications in the Management of Anorexia Nervosa: Rationale, Evidence and Future Prospects.
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DOI：
10.1007/s40263-016-0335-6
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发表时间：
2016-05
期刊：
影响因子：
6
通讯作者：
Shott ME
中科院分区：
文献类型：
--
作者：
Frank GK;Shott ME
神经性厌食症是一种严重的精神疾病，没有批准的药物干预。每一类精神活性药物都试图改善治疗结果;然而，随机对照试验充其量是模棱两可的，而且各项研究都没有显示出体重增加和恢复的有力改善。在这里，我们回顾了可用的文献药物干预神经性厌食症来更大的公众认可，在20世纪60年代。这将包括对这些试验可能没有成功的原因进行严格审查。我们进一步提供了这种疾病的神经生物学背景，并讨论了认知，学习和情绪调节回路如何成为未来的治疗目标。尽一切努力为神经性厌食症开发有效的药物治疗方案势在必行，因为它仍然是一种复杂的精神疾病，疾病负担和死亡率都很高。
Anorexia nervosa is a severe psychiatric disorder without approved medication intervention. Every class of psychoactive medication has been tried to improve treatment outcome; however, randomized controlled trials have been ambiguous at best and across studies have not shown robust improvements in weight gain and recovery. Here we review the available literature on pharmacological interventions since anorexia nervosa came to greater public recognition in the 1960s. This will include a critical review of why those trials may not have been successful. We further provide a neurobiological background for the disorder and discuss how cognition, learning and emotion-regulating circuits could become treatment targets in the future. Making every effort to develop effective pharmacological treatment options for anorexia nervosa is imperative, as it continues to be a complex psychiatric disorder with high disease burden and mortality.