Mortality and morbidity of HIV infected patients receiving HAART: A cohort study
Mortality and morbidity of HIV infected patients receiving HAART: A cohort study
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DOI：
10.2174/157016208784324976
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发表时间：
2008-05-01
影响因子：
1
通讯作者：
Falagas, Matthew E.
中科院分区：
文献类型：
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作者：
Panos, George;Samonis, George;Falagas, Matthew E.
HAART大大降低了艾滋病毒感染患者的死亡率和发病率。我们回顾分析了一组长期和频繁随访的艾滋病病毒感染成人患者的发病率和死亡率(19872006)。出于比较的原因，这项研究被分为HAART前和HAART期间。总共有615名HIV感染者(54名女性)被纳入我们的研究。144人在HAART前期间死亡(每100名患者中有51.4人死亡)。在HAART期间，接受HAART治疗的335名患者中只有38名患者死亡(每100名患者中有11.3名死亡)；这部分队列中的随访为2139人年，死亡率为1.77人/每100人年。不包括入院后3个月内死亡的患者的子分析显示，从确诊时开始接受HAART的患者的死亡率(每100人年1.2例死亡)略低于接受非HAART治疗一段时间的患者的死亡率(每100人年1.58例死亡)。在该病房采用抗艾滋病抗逆转录病毒治疗后，非艾滋病相关死亡的比例从8%显著增加到40%(p<；0.001)；感染仍然是两组患者的主要死亡原因。最常见的非艾滋病相关死因是癌症和冠心病。我们来自研究队列的数据补充了有关HAART后发病率和死亡率显著降低的相关文献。
HAART has substantially decreased mortality and morbidity among HIV-infected patients. We retrospectively analyzed morbidity and mortality in a cohort of HIV-infected adult patients with prolonged and frequent follow up ( 19872006). The study was divided in pre-HAART and HAART period for comparative reasons. In total, 615 HIV-infected patients ( 54 females) were included in our study. 144 died during the pre-HAART period (51.4 deaths per 100 patients). During the HAART period only 38 patients died from a total of 335 patients receiving HAART (11.3 deaths per 100 patients); the follow up in this part of the cohort was 2139 persons-years and the death incidence 1.77 deaths/per 100 person-years. The subanalysis excluding patients who died within 3 months from admission showed that death incidence among patients that have been receiving HAART from the time of diagnosis (1.2 deaths per 100 person-years) was slightly lower, compared to the death incidence of patients treated for some time with non-HAART as well (1.58 deaths per 100 persons-years). After the availability of HAART in this unit, the proportion of non-AIDS related deaths increased significantly from 8% to 40% (p < 0.001); infections remained the leading cause of death in both groups of patients. he most common non-AIDS related causes of deaths were cancer and coronary disease. Our data from the studied cohort adds to the relevant literature regarding the dramatic reduction of morbidity and mortality that occurred after the availability of HAART.