BILE-ACID POOL CHANGES AND REGULATION OF CHOLATE SYNTHESIS IN EXPERIMENTAL DIABETES
BILE-ACID POOL CHANGES AND REGULATION OF CHOLATE SYNTHESIS IN EXPERIMENTAL DIABETES
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DOI：
10.1016/0005-2760(78)90064-4
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发表时间：
1978-01-01
期刊：
影响因子：
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通讯作者：
VALDIVIESO, VD
中科院分区：
文献类型：
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作者：
NERVI, FO;SEVERIN, CH;VALDIVIESO, VD
在大鼠中研究了四氧嘧啶糖尿病和胰岛素治疗对胆汁酸池大小和组成、胆汁酸分泌和胆酸合成的影响。糖尿病诱导后4天，胆酸盐池的大小显著增加。糖尿病2周后，它达到了恒定的大小，是对照组动物的3倍。胆汁酸池大小和分泌的变化直接依赖于胰岛素缺乏状态，因为它们被胰岛素治疗逆转，并且不受动物的热量摄入或四氧嘧啶的药理作用的影响。糖尿病大鼠的胆汁胆汁酸盐分泌也增加了3倍，占总胆汁酸的80%以上，而对照组为60%。在糖尿病大鼠中计算的每日胆酸盐合成速率增加，并且在这种情况下胆酸盐合成的昼夜节律被废除。调节胆汁酸合成的负反馈机制在糖尿病中被删除，并在胰岛素治疗2周后部分恢复。四氧嘧啶糖尿病大鼠胆汁酸代谢发生显著变化。胰岛素可能在调节胆汁酸合成和肠道吸收中起重要作用。
The effect of alloxan-diabetes and insulin treatment in bile acid pool size and composition, bile acid secretion and cholic acid synthesis was investigated in the rat. The size of the cholate pool was significantly increased 4 days after diabetes induction. It reached a constant size 3 times that of control animals after 2 wk of diabetes. Changes in bile acid pool size and secretion were directly dependent on the insulin deficiency state since they were reversed by insulin treatment and were not influenced by the caloric intake of the animal nor the pharmacologic effect of alloxan. Biliary cholate secretion was also 3-fold increased in diabetic rats and it accounted for more than 80% of the total bile acids compared to 60% in the control group. The calculated daily rate of cholate synthesis was increased in diabetic rats and the circadian rhythm of cholate synthesis was abolished in this condition. The negative feedback mechanism that regulates bile acid synthesis was deleted in diabetes and was partially restored after 2 wk of insulin treatment. Bile acid metabolism was profoundly changed in alloxan-diabetic rats. Insulin may play an important role in the regulation of bile acid synthesis and intestinal absorption.