Neurotrophic factors: Are they axon guidance molecules?
Neurotrophic factors: Are they axon guidance molecules?
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DOI：
10.1007/978-0-387-76715-4_6
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发表时间：
2007-01-01
期刊：
影响因子：
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通讯作者：
Guthrie, Sarah
中科院分区：
文献类型：
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作者：
Guthrie, Sarah
神经营养因子在发育过程中发挥着多种作用。它们能在体外促进轴突生长，并能定向轴突。最近，分子证据表明，神经营养因子和轴突引导分子在神经元中调节相同的信号通路。然而，只有少数几项关键研究测试了神经营养因子在体内作为指导分子的可能作用。在这一章中，我回顾了支持和反对神经营养因子作为轴突引导分子的证据。
Neurotrophic factors play a multiplicity of roles during development. They can promote axonal growth in vitro and are capable of orienting axons. Recently, molecular evidence suggests that neurotrophic factors and axon guidance molecules reglate the same signalling pathways in neurons. Yet only a few critical studies have tested a possible role for neurotrophic factors as guidance molecules in vivo. In this chapter I review the evidence for and against neurotrophic factors as axon guidance molecules.