Synthesis of 2'-O,4'-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C-3,-endo sugar puckering

Synthesis of 2'-O,4'-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C-3,-endo sugar puckering
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DOI:
10.1016/s0040-4039(97)10322-7
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发表时间:
1997-12-15
影响因子:
1.8
通讯作者:
Imanishi, T
Imanishi, T
中科院分区:
化学4区
文献类型:
--
作者:
Obika, S;Nanbu, D;Imanishi, T

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以尿苷为起始原料,经多步反应合成了具有典型C3 ′-内糖褶皱结构的新型双环核苷类似物2 ′-O,4 ′-C-亚甲基尿苷和2 ′-胞苷。(C)1997年爱思唯尔科学有限公司
2'-O,4'-C-Methyleneuridine and -cytidine, novel bicyclic nucleoside analogs having a typical C3'-endo sugar puckering, were synthesized starting from uridine via a several-step sequence. (C) 1997 Elsevier Science Ltd.